Existence and stability of steady states of a reaction convection diffusion equation modeling microtubule formation
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Abstract: We generalize the Dogterom-Leibler model for microtubule dynamics [DL] to the case where the rates of elongation as well as the lifetimes of the elongating and shortening phases are a function of GTP-tubulin concentration. We study also the effect of nucleation rate in the form of a damping term which leads to new steady-states. For this model, we study existence and stability of steady states satisfying the boundary conditions at x = 0. Our stability analysis introduces numerical and analytical Evans function computations as a new mathematical tool in the study of microtubule dynamics.
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Cited in
(5)- Phase transition analysis of the dynamic instability of microtubules
- Efficient numerical stability analysis of detonation waves in ZND
- Polymerization of microtubules in the presence of diffusing tubulins: a boundary layer analysis
- Decreasing renewal dichotomous Markov noise shock model with hypothesis testing applications
- Spatial pattern formation in microtubule post-translational modifications and the tight localization of motor-driven cargo
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