Is maximum tolerated dose (MTD) chemotherapy scheduling optimal for glioblastoma multiforme?

DOI10.1016/J.CNSNS.2024.108292MaRDI QIDQ6604202zbMATH OpenFDO

Authors Chiu-Yen Kao, Seyyed Abbas Mohammadi, Mohsen Yousefnezhad

Publication date 12 September 2024

Published in Communications in Nonlinear Science and Numerical Simulation (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/J.CNSNS.2024.108292

zbMATH Keywords

analytical solutionbang-bang solutionchemotherapy schedulingglioblastoma multiformeoptimal control of PDEs

Mathematics Subject Classification ID

Reaction-diffusion equations (35K57) Existence theories for optimal control problems involving partial differential equations (49J20) Existence of optimal solutions belonging to restricted classes (Lipschitz controls, bang-bang controls, etc.) (49J30) Medical applications (general) (92C50)

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Cites work

• A review of optimal chemotherapy protocols: from MTD towards metronomic therapy
• scientific article; zbMATH DE number 5703572 (Why is no real title available?)
• Mathematical biology. Vol. 2: Spatial models and biomedical applications.
• Mathematical oncology: using mathematics to enable cancer discoveries
• Maximization of viability time in a mathematical model of cancer therapy
• Minimization of Region-Scalable Fitting Energy for Image Segmentation
• Nonlinear partial differential equations with applications
• On the MTD paradigm and optimal control for multi-drug cancer chemotherapy
• Optimal Chemotherapy for Brain Tumor Growth in a Reaction-Diffusion Model
• Optimal control of advective direction in reaction-diffusion population models
• Ultimate dynamics and optimal control of a multi-compartment model of tumor resistance to chemotherapy

Cited in

(1)

• The diffusion determination in a reaction-diffusion system by application of Dubovitskii-Milyutin's formalism

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