A mathematical model for breath gas analysis of volatile organic compounds with special emphasis on acetone
From MaRDI portal
(Redirected from Publication:662571)
Abstract: Recommended standardized procedures for determining exhaled lower respiratory nitric oxide and nasal nitric oxide have been developed by task forces of the European Respiratory Society and the American Thoracic Society. These recommendations have paved the way for the measurement of nitric oxide to become a diagnostic tool for specific clinical applications. It would be desirable to develop similar guidelines for the sampling of other trace gases in exhaled breath, especially volatile organic compounds (VOCs) which reflect ongoing metabolism. The concentrations of water-soluble, blood-borne substances in exhaled breath are influenced by: (i) breathing patterns affecting gas exchange in the conducting airways; (ii) the concentrations in the tracheo-bronchial lining fluid; (iii) the alveolar and systemic concentrations of the compound. The classical Farhi equation takes only the alveolar concentrations into account. Real-time measurements of acetone in end-tidal breath under an ergometer challenge show characteristics which cannot be explained within the Farhi setting. Here we develop a compartment model that reliably captures these profiles and is capable of relating breath to the systemic concentrations of acetone. By comparison with experimental data it is inferred that the major part of variability in breath acetone concentrations (e.g., in response to moderate exercise or altered breathing patterns) can be attributed to airway gas exchange, with minimal changes of the underlying blood and tissue concentrations. Moreover, it is deduced that measured end-tidal breath concentrations of acetone determined during resting conditions and free breathing will be rather poor indicators for endogenous levels. Particularly, the current formulation includes the classical Farhi and the Scheid series inhomogeneity model as special limiting cases.
Recommendations
- Physiological modeling of isoprene dynamics in exhaled breath
- Analysis and characterization of diffusive flows and movement of the human acinar region: an experimentally validated CFD model
- scientific article; zbMATH DE number 3920267
- Simplified models for gas exchange in the human lungs
- scientific article; zbMATH DE number 7527900
Cites work
- A mathematical model for breath gas analysis of volatile organic compounds with special emphasis on acetone
- Applied Mathematical Models in Human Physiology
- scientific article; zbMATH DE number 4009690 (Why is no real title available?)
- scientific article; zbMATH DE number 46299 (Why is no real title available?)
- scientific article; zbMATH DE number 47820 (Why is no real title available?)
- scientific article; zbMATH DE number 108341 (Why is no real title available?)
- scientific article; zbMATH DE number 758785 (Why is no real title available?)
- scientific article; zbMATH DE number 5263362 (Why is no real title available?)
- scientific article; zbMATH DE number 961607 (Why is no real title available?)
- Maximum likelihood estimation in nonlinear mixed effects models
- Monotone chemical reaction networks
- Monotone control systems
- Nonlinear controllability and observability
- NONLINEAR DYNAMICAL SYSTEM IDENTIFICATION FROM UNCERTAIN AND INDIRECT MEASUREMENTS
- Numerical parameter identifiability and estimability: Integrating identifiability, estimability, and optimal sampling design
- On the Global Stability of Cooperative Systems
- Orders of Input/Output Differential Equations and State-Space Dimensions
- Parameter estimation in nonlinear delayed feedback systems from noisy data
- PARAMETER IDENTIFICATION TECHNIQUES FOR PARTIAL DIFFERENTIAL EQUATIONS
- Single-input observability of continuous-time systems
- Solving Ordinary Differential Equations I
- Statistical methods for model comparison in parameter estimation problems for distributed systems
- Theoretical basis of single breath gas absorption tests
Cited in
(3)
This page was built for publication: A mathematical model for breath gas analysis of volatile organic compounds with special emphasis on acetone
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q662571)
