Analysis of singularly perturbed stochastic chemical reaction networks motivated by applications to epigenetic cell memory

DOI10.1137/23M1592389MaRDI QIDQ6629685FDOQ6629685

Authors: Simone Bruno, Felipe A. Campos, Yi Fu, Domitilla Del Vecchio, R. J. Williams 

Publication date: 30 October 2024

Published in: SIAM Journal on Applied Dynamical Systems (Search for Journal in Brave)

zbMATH Keywords

singular perturbationmean first passage timescontinuous time Markov chainepigenetic cell memorychromatin modification circuitsmultimodal stationary distribution

Mathematics Subject Classification ID

Applications of continuous-time Markov processes on discrete state spaces (60J28) Biochemistry, molecular biology (92C40) Systems biology, networks (92C42)

Cites Work

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• A singular perturbation approach to modeling and control of Markov chains
• The first Laurent series coefficients for singularly perturbed stochastic matrices
• Comparison theorems for stochastic chemical reaction networks
• H infintity control of large-scale jump linear systems via averaging and aggregation

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