Practical identifiability and uncertainty quantification of a pulsatile cardiovascular model
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Publication:669033
Abstract: Mathematical models are essential tools to study how the cardiovascular system maintains homeostasis. The utility of such models is limited by the accuracy of their predictions, which can be determined by uncertainty quantification (UQ). A challenge associated with the use of UQ is that many published methods assume that the underlying model is identifiable (e.g. that a one-to-one mapping exists from the parameter space to the model output). In this study we present a novel methodology that is used here to calibrate a lumped-parameter model to left ventricular pressure and volume time series data sets. Key steps include using (1) literature and available data to determine nominal parameter values; (2) sensitivity analysis and subset selection to determine a set of identifiable parameters; (3) optimization to find a point estimate for identifiable parameters; and (4) frequentist and Bayesian UQ calculations to assess the predictive capability of the model. Our results show that it is possible to determine 5 identifiable model parameters that can be estimated to our experimental data from three rats, and that computed UQ intervals capture the measurement and model error.
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Cites work
- A practical approach to parameter estimation applied to model predicting heart rate regulation
- An adaptive Metropolis algorithm
- Applied Mathematical Models in Human Physiology
- Cardiovascular mathematics. Modeling and simulation of the circulatory system
- Development of Patient Specific Cardiovascular Models Predicting Dynamics in Response to Orthostatic Stress Challenges
- Estimation and identification of parameters in a lumped cerebrovascular model
- Filtering via Simulation: Auxiliary Particle Filters
- Fluid mechanics of heart valves and their replacements
- Gaussian processes for machine learning.
- Generalized sensitivities and optimal experimental design
- scientific article; zbMATH DE number 1666093 (Why is no real title available?)
- scientific article; zbMATH DE number 1274356 (Why is no real title available?)
- scientific article; zbMATH DE number 3321507 (Why is no real title available?)
- scientific article; zbMATH DE number 5180707 (Why is no real title available?)
- Linear multistep methods, particle filtering and sequential Monte Carlo
- Markov Chain Monte Carlo Convergence Diagnostics: A Comparative Review
- Modeling the heart and the circulatory system
- On identifiability of nonlinear ODE models and applications in viral dynamics
- On Metropolis-Hastings algorithms with delayed rejection
- On the efficiency of certain quasi-random sequences of points in evaluating multi-dimensional integrals
- Parameter estimation for stiff deterministic dynamical systems via ensemble Kalman filter
- Patient-specific modelling of head-up tilt
- Pulse wave propagation in the arterial tree
- Rank-deficient nonlinear least squares problems and subset selection
- Relating mechanics, blood flow and mass transport in the cardiac muscle
- Remark on algorithm 659
- Sparse grids
- Statistical and computational inverse problems.
- Structural correlation method for model reduction and practical estimation of patient specific parameters illustrated on heart rate regulation
- The complex-step derivative approximation
- The ensemble Kalman filter for combined state and parameter estimation
Cited in
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- Uncertainty propagation and sensitivity analysis: results from the ocular mathematical virtual simulator
- Uncertainty quantification of simulated biomechanical stimuli in coronary artery bypass grafts
- Global sensitivity analysis informed model reduction and selection applied to a Valsalva maneuver model
- Patient-specific parameter estimation: coupling a heart model and experimental data
- Parameter estimation for closed-loop lumped parameter models of the systemic circulation using synthetic data
- Mathematical modelling of atrial and ventricular pressure-volume dynamics and their change with heart rate
- Multilevel and multifidelity uncertainty quantification for cardiovascular hemodynamics
- Mathematical modeling and sensitivity analysis of arterial anastomosis in the arm
- Cardiovascular dynamics during head-up tilt assessed via pulsatile and non-pulsatile models
- Estimability analysis and optimal design in dynamic multi-scale models of cardiac electrophysiology
- Modelling and disentangling physiological mechanisms: linear and nonlinear identification techniques for analysis of cardiovascular regulation
- INFERENCE OF SYSTEMS WITH DELAY AND APPLICATIONS TO CARDIOVASCULAR DYNAMICS
- Unraveling autonomic cardiovascular control complexity during orthostatic stress: insights from a mathematical model
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