Semiparametric regression in testicular germ cell data

DOI10.1214/12-AOAS552zbMATH Open1254.62056arXiv1005.5494OpenAlexW3100037703MaRDI QIDQ714374FDOQ714374

Authors: Anastasia Voulgaraki, Barry I. Graubard, Benjamin Kedem-Kimelfeld 

Publication date: 21 October 2012

Published in: The Annals of Applied Statistics (Search for Journal in Brave)

Abstract: It is possible to approach regression analysis with random covariates from a semiparametric perspective where information is combined from multiple multivariate sources. The approach assumes a semiparametric density ratio model where multivariate distributions are "regressed" on a reference distribution. A kernel density estimator can be constructed from many data sources in conjunction with the semiparametric model. The estimator is shown to be more efficient than the traditional single-sample kernel density estimator, and its optimal bandwidth is discussed in some detail. Each multivariate distribution and the corresponding conditional expectation (regression) of interest are estimated from the combined data using all sources. Graphical and quantitative diagnostic tools are suggested to assess model validity. The method is applied in quantifying the effect of height and age on weight of germ cell testicular cancer patients. Comparisons are made with multiple regression, generalized additive models (GAM) and nonparametric kernel regression.

Full work available at URL: https://arxiv.org/abs/1005.5494

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zbMATH Keywords

kernelGAMdiagnosticsrandom covariatesmultivariate density ratio modelNadaraya-Watson

Mathematics Subject Classification ID

Density estimation (62G07) Nonparametric regression and quantile regression (62G08) Applications of statistics to biology and medical sciences; meta analysis (62P10) Medical applications (general) (92C50) Estimation in multivariate analysis (62H12) Graphical methods in statistics (62A09)

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Cited In (9)

• Semiparametric Regression of Multidimensional Genetic Pathway Data: Least‐Squares Kernel Machines and Linear Mixed Models
• Estimation of residential radon concentration in Pennsylvania counties by data fusion
• Semiparametric empirical likelihood confidence intervals for AUC under a density ratio model
• Semiparametric regression in testicular germ cell data
• Out-of-sample fusion in risk prediction
• Bayesian semiparametric density ratio modelling with applications to medical malpractice reform
• Semiparametric estimation of treatment effect with density ratio model
• Nonparametric estimation of the ROC curve for length-biased and right-censored data
• A new classifier for imbalanced data based on a generalized density ratio model

Uses Software

• gamair

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