Microscopic reversibility or detailed balance in ion channel models

DOI10.1007/S10910-011-9961-XzbMATH Open1401.92093arXiv1109.4262OpenAlexW2027221818WikidataQ122750773 ScholiaQ122750773MaRDI QIDQ714676FDOQ714676

Authors: D. Kharzeev 

Publication date: 11 October 2012

Published in: Journal of Mathematical Chemistry (Search for Journal in Brave)

Abstract: Mass action type deterministic kinetic models of ion channels are usually constructed in such a way as to obey the principle of detailed balance (or, microscopic reversibility) for two reasons: first, the authors aspire to have models harmonizing with thermodynamics, second, the conditions to ensure detailed balance reduce the number of reaction rate coefficients to be measured. We investigate a series of ion channel models which are asserted to obey detailed balance, however, these models violate mass conservation and in their case only the necessary conditions (the so-called circuit conditions) are taken into account. We show that ion channel models have a very specific structure which makes the consequences true in spite of the imprecise arguments. First, we transform the models into mass conserving ones, second, we show that the full set of conditions ensuring detailed balance (formulated by Feinberg) leads to the same relations for the reaction rate constants in these special cases, both for the original models and the transformed ones.

Full work available at URL: https://arxiv.org/abs/1109.4262

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zbMATH Keywords

ion channelsdetailed balancecircuit conditionsmicroscopic reversibilityspanning forest conditions

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Cites Work

• Zur Umkehrbarkeit der statistischen Naturgesetze
• Investigation of transmitter-receptor interactions by analyzing postsynaptic membrane noise using stochastic kinetics

Cited In (4)

• Convergence in nonautonomous linear differential equations with Kirchhoff coefficients
• On detailed balance and reversibility of semi-Markov processes and single-molecule enzyme kinetics
• A comparative tool for the validity of rate kinetics in ion channels by Onsager reciprocity theorem
• Structural analysis of combustion mechanisms

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