Generalized Poland-Scheraga denaturation model and two-dimensional renewal processes
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Abstract: The Poland-Scheraga model describes the denaturation transition of two complementary - in particular, equally long - strands of DNA, and it has enjoyed a remarkable success both for quantitative modeling purposes and at a more theoretical level. The solvable character of the homogeneous version of the model is one of features to which its success is due. In the bio-physical literature a generalization of the model, allowing different length and non complementarity of the strands, has been considered and the solvable character extends to this substantial generalization. We present a mathematical analysis of the homogeneous generalized Poland-Scheraga model. Our approach is based on the fact that such a model is a homogeneous pinning model based on a bivariate renewal process, much like the basic Poland-Scheraga model is a pinning model based on a univariate, i.e. standard, renewal. We present a complete analysis of the free energy singularities, which include the localization-delocalization critical point and (in general) other critical points that have been only partially captured in the physical literature. We obtain also precise estimates on the path properties of the model.
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Cited in
(11)- scientific article; zbMATH DE number 4001927 (Why is no real title available?)
- Lifson-Poland-Scheraga models of DNA
- Localization, big-jump regime and the effect of disorder for a class of generalized pinning models
- Strong renewal theorems and local large deviations for multivariate random walks and renewals
- Critical fluctuations in renewal models of statistical mechanics
- Poland-Scheraga models and the DNA denaturation transition
- Scaling limit of the disordered generalized Poland-Scheraga model for DNA denaturation
- Influence of disorder on DNA denaturation: the disordered generalized Poland-Scheraga model
- Disorder and denaturation transition in the generalized Poland-Scheraga model
- Polarobreathers in a generalized Holstein model
- DNA melting structures in the generalized Poland-Scheraga model
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