The phenotypic equilibrium of cancer cells: from average-level stability to path-wise convergence

DOI10.1016/J.JTBI.2015.09.001MaRDI QIDQ739770zbMATH OpenOpenAlexWikidataFDO

Authors Yuanling Niu, Yue Wang, Da Zhou

Publication date 19 August 2016

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1502.06089

zbMATH Keywords

stochastic simulationcancer stem cellphenotypic plasticitymulti-phenotype branching process

Mathematics Subject Classification ID

Medical applications (general) (92C50) Applications of branching processes (60J85)

Abstract: The phenotypic equilibrium, i.e. heterogeneous population of cancer cells tending to a fixed equilibrium of phenotypic proportions, has received much attention in cancer biology very recently. In previous literature, some theoretical models were used to predict the experimental phenomena of the phenotypic equilibrium, which were often explained by different concepts of stabilities of the models. Here we present a stochastic multi-phenotype branching model by integrating conventional cellular hierarchy with phenotypic plasticity mechanisms of cancer cells. Based on our model, it is shown that: (i) our model can serve as a framework to unify the previous models for the phenotypic equilibrium, and then harmonizes the different kinds of average-level stabilities proposed in these models; and (ii) path-wise convergence of our model provides a deeper understanding to the phenotypic equilibrium from stochastic point of view. That is, the emergence of the phenotypic equilibrium is rooted in the stochastic nature of (almost) every sample path, the average-level stability just follows from it by averaging stochastic samples.

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Cites work

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Cited in

(6)

• Stochastic stem cell models with mutation: a comparison of asymmetric and symmetric divisions
• Inference on autoregulation in gene expression with variance-to-mean ratio
• The overshoot and phenotypic equilibrium in characterizing cancer dynamics of reversible phenotypic plasticity
• On tumoural growth and treatment under cellular dedifferentiation
• A Bayesian statistical analysis of stochastic phenotypic plasticity model of cancer cells
• Cell population growth kinetics in the presence of stochastic heterogeneity of cell phenotype

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