The phenotypic equilibrium of cancer cells: from average-level stability to path-wise convergence

DOI10.1016/J.JTBI.2015.09.001zbMATH Open1343.92241arXiv1502.06089OpenAlexW1613472591WikidataQ50855354 ScholiaQ50855354MaRDI QIDQ739770FDOQ739770

Yuanling Niu, Yue Wang, Da Zhou

Publication date: 19 August 2016

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Abstract: The phenotypic equilibrium, i.e. heterogeneous population of cancer cells tending to a fixed equilibrium of phenotypic proportions, has received much attention in cancer biology very recently. In previous literature, some theoretical models were used to predict the experimental phenomena of the phenotypic equilibrium, which were often explained by different concepts of stabilities of the models. Here we present a stochastic multi-phenotype branching model by integrating conventional cellular hierarchy with phenotypic plasticity mechanisms of cancer cells. Based on our model, it is shown that: (i) our model can serve as a framework to unify the previous models for the phenotypic equilibrium, and then harmonizes the different kinds of average-level stabilities proposed in these models; and (ii) path-wise convergence of our model provides a deeper understanding to the phenotypic equilibrium from stochastic point of view. That is, the emergence of the phenotypic equilibrium is rooted in the stochastic nature of (almost) every sample path, the average-level stability just follows from it by averaging stochastic samples.

Full work available at URL: https://arxiv.org/abs/1502.06089

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zbMATH Keywords

stochastic simulationcancer stem cellphenotypic plasticitymulti-phenotype branching process

Mathematics Subject Classification ID

Medical applications (general) (92C50) Applications of branching processes (60J85)

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Cited In (6)

• On tumoural growth and treatment under cellular dedifferentiation
• The overshoot and phenotypic equilibrium in characterizing cancer dynamics of reversible phenotypic plasticity
• Inference on autoregulation in gene expression with variance-to-mean ratio
• Cell population growth kinetics in the presence of stochastic heterogeneity of cell phenotype
• A Bayesian statistical analysis of stochastic phenotypic plasticity model of cancer cells
• Stochastic stem cell models with mutation: a comparison of asymmetric and symmetric divisions

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