Inference of signaling and gene regulatory networks by steady-state perturbation experiments: structure and accuracy

DOI10.1016/J.JTBI.2004.08.022MaRDI QIDQ776529zbMATH OpenOpenAlexWikidataFDO

Authors Michael Andrec, Boris N. Kholodenko, Ronald M. Levy, Eduardo D. Sontag

Publication date 9 July 2020

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2004.08.022

zbMATH Keywords

systems biologymodulereverse engineeringunravellingblack box

Mathematics Subject Classification ID

Systems biology, networks (92C42) Cell biology (92C37) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

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Cites work

• scientific article; zbMATH DE number 4213315 (Why is no real title available?)
• scientific article; zbMATH DE number 51511 (Why is no real title available?)
• scientific article; zbMATH DE number 1748542 (Why is no real title available?)
• scientific article; zbMATH DE number 236854 (Why is no real title available?)
• An Analysis of the Total Least Squares Problem
• Ratios of Normal Variables and Ratios of Sums of Uniform Variables
• Statistical Analysis of Spherical Data
• Structured total least squares and \(L_ 2\) approximation problems
• THE DISTRIBUTION OF THE INDEX IN A NORMAL BIVARIATE POPULATION

Cited in

(12)

• Inferring intracellular signal transduction circuitry from molecular perturbation experiments
• Signal propagation in small-world biological networks with weak noise
• Inferring gene regulatory networks from temporal expression profiles under time-delay and noise
• Exact probabilities for the indeterminacy of complex networks as perceived through press perturbations
• Randomized approximation algorithms for set multicover problems with applications to reverse engineering of protein and gene networks
• Inferring stable genetic networks from steady-state data
• Direct response analysis in cellular signalling networks
• A mathematical program to refine gene regulatory networks
• Generalized analysis of experimental data for interrelated biological measurements
• Approximating the online set multicover problems via randomized winnowing
• Molecular systems biology and control
• Fitting Boolean networks from steady state perturbation data

Describes a project that uses

Uses Software

• LINPACK

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