The early growth of cancer

DOI10.1007/BF00276231MaRDI QIDQ802483zbMATH OpenWikidataFDO

Authors Joshua Chover, James H. King

Publication date 1985

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/BF00276231

zbMATH Keywords

cancer kineticscarcinogenesis-modelsestimationgrowth rateshepatocellular fociinitial growth of cancerous tumorsinitial size of the growth cloneinitial time of growthscaling factorstesttumor size distributions

Mathematics Subject Classification ID

Applications of branching processes (60J85) Medical applications (general) (92C50)

Review text

In this paper, we compare two types of stochastic models for the initial growth of cancerous tumors. In one type, the random element enters via the initial time of growth or via the initial size of the growth clone. In the other type, tumors differ from one another essentially via their growth rates. We present a simple test to distinguish between the two types when tumor size distributions are available from several time points. Size distributions are the key elements of such kinetic analysis given the limitation that an individual tumor can be measured only once, at the time of sacrifice of an experimental animal. We discuss these concepts in connection with data from particular experiments on carcinogenic growth in the livers of mice.

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Cites work

• scientific article; zbMATH DE number 3555176 (Why is no real title available?)
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Cited in

(7)

• The particular role of cell loss in tumor growth
• Dynamics of tumor interaction with the host immune system
• From population dynamics to modelling the competition between tumors and immune system
• Tests for Differences in Tumor Incidence Based on Animal Carcinogenesis Experiments
• Modeling Tumor Growth with Random Onset
• Some stochastic models op cancer metastases
• Estimating tumor growth rates in vivo

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