Bifurcation for a free boundary problem modeling a small arterial plaque
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Publication:831091
Abstract: Atherosclerosis, hardening of the arteries, originates from small plaque in the arteries; it is a major cause of disability and premature death in the United States and worldwide. In this paper, we study the bifurcation of a highly nonlinear and highly coupled PDE model describing the growth of arterial plaque in the early stage of atherosclerosis. The model involves LDL and HDL cholesterols, macrophage cells as well as foam cells, with the interface separating the plaque and blood flow regions being a free boundary. We establish finite branches of symmetry-breaking stationary solutions which bifurcate from the radially symmetric solution. Since plaque in reality is unlikely to be strictly radially symmetric, our result would be useful to explain the asymmetric shapes of plaque.
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Cites work
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- scientific article; zbMATH DE number 2074374 (Why is no real title available?)
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Cited in
(12)- Symmetry-breaking longitude bifurcations for a free boundary problem modeling small plaques in three dimensions
- Periodic solution for a free boundary problem modeling small plaques
- A free boundary mathematical model of atherosclerosis
- Error analysis of finite difference/collocation method for the nonlinear coupled parabolic free boundary problem modeling plaque growth in the artery
- Bifurcation for a free boundary model of an atherosclerotic plaque formation in the presence of reverse cholesterol transport with Holling type III functional response
- Symmetry-breaking combined latitude-longitude bifurcations for a free boundary problem modeling small plaques
- On the first bifurcation point for a free boundary problem modeling a small arterial plaque
- Bifurcation analysis of a free boundary model of the atherosclerotic plaque formation associated with the cholesterol ratio
- Analysis on bifurcation solutions of an atherosclerosis model
- Bifurcation for a free-boundary problem modeling small plaques with reverse cholesterol transport
- Well-posedness of a free boundary problem of early atherosclerotic plaque formation with reverse cholesterol transport
- A free boundary problem for steady small plaques in the artery and their stability
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