Bifurcation for a free boundary problem modeling a small arterial plaque
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Publication:831091
DOI10.1016/J.JDE.2021.04.008zbMATH Open1466.92051arXiv2008.02407OpenAlexW3156610091WikidataQ116009450 ScholiaQ116009450MaRDI QIDQ831091FDOQ831091
Publication date: 10 May 2021
Published in: Journal of Differential Equations (Search for Journal in Brave)
Abstract: Atherosclerosis, hardening of the arteries, originates from small plaque in the arteries; it is a major cause of disability and premature death in the United States and worldwide. In this paper, we study the bifurcation of a highly nonlinear and highly coupled PDE model describing the growth of arterial plaque in the early stage of atherosclerosis. The model involves LDL and HDL cholesterols, macrophage cells as well as foam cells, with the interface separating the plaque and blood flow regions being a free boundary. We establish finite branches of symmetry-breaking stationary solutions which bifurcate from the radially symmetric solution. Since plaque in reality is unlikely to be strictly radially symmetric, our result would be useful to explain the asymmetric shapes of plaque.
Full work available at URL: https://arxiv.org/abs/2008.02407
Bifurcations in context of PDEs (35B32) Physiological flows (76Z05) Physiological flow (92C35) Pathology, pathophysiology (92C32)
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Cited In (8)
- Well-posedness of a free boundary problem of early atherosclerotic plaque formation with reverse cholesterol transport
- Bifurcation for a free boundary model of an atherosclerotic plaque formation in the presence of reverse cholesterol transport with Holling type III functional response
- Symmetry-breaking combined latitude-longitude bifurcations for a free boundary problem modeling small plaques
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