Stability in generic mitochondrial models
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Publication:839375
DOI10.1007/S10910-008-9464-6zbMATH Open1196.92007arXiv0706.3684OpenAlexW2024687804MaRDI QIDQ839375FDOQ839375
Authors: Pete Donnell, Murad Banaji, Stephen Baigent 
Publication date: 2 September 2009
Published in: Journal of Mathematical Chemistry (Search for Journal in Brave)
Abstract: In this paper, we use a variety of mathematical techniques to explore existence, local stability, and global stability of equilibria in abstract models of mitochondrial metabolism. The class of models constructed is defined by the biological description of the system, with minimal mathematical assumptions. The key features are an electron transport chain coupled to a process of charge translocation across a membrane. In the absence of charge translocation these models have previously been shown to behave in a very simple manner with a single, globally stable equilibrium. We show that with charge translocation the conclusion about a unique equilibrium remains true, but local and global stability do not necessarily follow. In sufficiently low dimensions - i.e. for short electron transport chains - it is possible to make claims about local and global stability of the equilibrium. On the other hand, for longer chains, these general claims are no longer valid. Some particular conditions which ensure stability of the equilibrium for chains of arbitrary length are presented.
Full work available at URL: https://arxiv.org/abs/0706.3684
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Biochemistry, molecular biology (92C40) Biophysics (92C05) Cell biology (92C37) Classical flows, reactions, etc. in chemistry (92E20)
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Cited In (8)
- \(P\)-matrices and signed digraphs
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- Graphical methods for analysing feedback in biological networks -- a survey
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- Computation of new degree-based topological indices of graphene
- Mathematical analysis of an \textit{in vivo} model of mitochondrial swelling
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