Within-host virus models with periodic antiviral therapy

DOI10.1007/S11538-008-9359-5zbMATH Open1169.92024arXiv0801.4384OpenAlexW2155135559WikidataQ45387952 ScholiaQ45387952MaRDI QIDQ841791FDOQ841791

Authors: Patrick De Leenheer 

Publication date: 18 September 2009

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Abstract: This paper investigates the effect of drug treatment on the standard within-host HIV model, assuming that therapy occurs periodically. It is shown that eradication is possible under these periodic regimes, and we quantitatively characterize successful drugs or drug combinations, both theoretically and numerically. We also consider certain optimization problems, motivated for instance, by the fact that eradication should be achieved at acceptable toxicity levels to the patient. It turns out that these optimization problems can be simplified considerably, and this makes calculations of the optima a fairly straightforward task. All our results will be illustrated by means of numerical examples based on up-to-date knowledge of parameter values in the model.

Full work available at URL: https://arxiv.org/abs/0801.4384

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zbMATH Keywords

optimizationinfluenzaHIVHBVmalariaHCVperiodic drug treatment

Mathematics Subject Classification ID

Medical applications (general) (92C50) Qualitative investigation and simulation of ordinary differential equation models (34C60) Applications of optimal control and differential games (49N90)

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Cited In (17)

• Stochastic dynamics of HIV models with switching parameters and pulse control
• Mathematical analysis of an HIV model with impulsive antiretroviral drug doses
• Within-host demographic fluctuations and correlations in early retroviral infection
• Permanence and extinction of a non-autonomous HIV-1 model with time delays
• Minimizing \(\mathcal R_0\) for in-host virus model with periodic combination antiviral therapy
• Within-host viral dynamics in a multi-compartmental environment
• Periodically varying antiviral therapies: conditions for global stability of the virus free state
• A mathematical model for HIV treatment with time-varying antiretroviral therapy
• Resonance of periodic combination antiviral therapy and intracellular delays in virus model
• A viral infection model with immune circadian rhythms
• A diffusive virus model with a fixed intracellular delay and combined drug treatments
• Periodic multidrug therapy in a within-host virus model
• Mathematical analysis of an HIV infection model including quiescent cells and periodic antiviral therapy
• A mathematical study of the implicit role of innate and adaptive immune responses on within-human \textit{Plasmodium falciparum} parasite levels
• A within-host virus model with periodic multidrug therapy
• A within-host virus model with multiple infected stages under time-varying environments
• Existence of positive periodic solutions of several types of biological models with periodic coefficients

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