Estimating protective vaccine efficacy from large trials with recruitment

DOI10.1016/J.JSPI.2006.06.016MaRDI QIDQ866637zbMATH OpenOpenAlexFDO

Authors Sergey Utev, Niels G. Becker, Claude Lefèvre

Publication date 14 February 2007

Published in Journal of Statistical Planning and Inference (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jspi.2006.06.016

zbMATH Keywords

asymptotic distributionestimationlower and upper boundsrandom vaccine responserecruiting trial participants

Mathematics Subject Classification ID

Asymptotic properties of parametric estimators (62F12) Applications of statistics to biology and medical sciences; meta analysis (62P10) Medical epidemiology (92C60)

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Cites work

• scientific article; zbMATH DE number 1741804 (Why is no real title available?)
• Approximating the Reed-Frost epidemic process
• Design issues for studies of infectious diseases
• Epidemics with two levels of mixing
• Estimating vaccine effects on transmission of infection from household outbreak data
• Estimating vaccine efficacy from small outbreaks
• Limit theorems for multitype epidemics
• On critical vaccination coverage in multitype epidemics
• Stochastic multitype epidemics in a community of households: Estimation of threshold parameter R and secure vaccination coverage

Cited in

(11)

• On the distribution of vaccine protection under heterogeneous response
• Endpoints in vaccine trials
• Leaky vaccines protect highly exposed recipients at a lower rate: implications for vaccine efficacy estimation and sieve analysis
• Heterogeneity in disease risk induces falling vaccine protection with rising disease incidence
• Estimation and interpretation of heterogeneous vaccine efficacy against recurrent infections
• Discussion on “Estimating vaccine efficacy over time after a randomized study is unblinded” by Anastasios A. Tsiatis and Marie Davidian
• Assessing the effect of an influenza vaccine in an encouragement design
• Estimating strain-specific and overall efficacy of polyvalent vaccines against recurrent pathogens from a cross-sectional study
• Estimating correlations between vaccine clinical trial outcomes
• Estimating Vaccine Efficacy Over Time After a Randomized Study is Unblinded
• Design of vaccine trials during outbreaks with and without a delayed vaccination comparator

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