Estimating correlations between vaccine clinical trial outcomes

DOI10.1080/02664763.2021.1949439MaRDI QIDQ5044656zbMATH OpenOpenAlexFDO

Authors Alexey Rey, Sergey Zhuk, Olga Rozanova

Publication date 2 November 2022

Published in Journal of Applied Statistics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1080/02664763.2021.1949439

zbMATH Keywords

factor modelsclinical trialsmaximum likelihoodlatent variablescorrelationsapplications of statistics

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Applications of statistics to economics (62P20) Applications of statistics (62Pxx)

Recommendations

• Statistics in clinical vaccine trials
• Statistics in clinical and observational vaccine studies
• Estimating protective vaccine efficacy from large trials with recruitment
• Estimating Vaccine Efficacy Over Time After a Randomized Study is Unblinded
• A Partial Likelihood Estimator of Vaccine Efficacy
• Design and estimation for evaluating principal surrogate markers in vaccine trials
• Hypotheses tests of strain-specific vaccine efficacy adjusted for covariate effects

Cites work

• A Random-Effects Ordinal Regression Model for Multilevel Analysis
• A multivariate probit latent variable model for analyzing dichotomous responses
• Analysis of multivariate probit models
• Classical latent variable models for medical research
• Latent variable models and factor analysis. A unified approach
• Two-dimensional toxic dose and multivariate logistic regression, with application to decompression sickness

Cited in

(1)

• Evaluating principal surrogate markers in vaccine trials in the presence of multiphase sampling

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