Differentiated cell behavior: a multiscale approach using measure theory
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Publication:887397
DOI10.1007/S00285-014-0846-ZzbMATH Open1331.35350arXiv1108.1212OpenAlexW2076269675WikidataQ51018189 ScholiaQ51018189MaRDI QIDQ887397FDOQ887397
Authors: Annachiara Colombi, M. Scianna, Andrea Tosin 
Publication date: 26 October 2015
Published in: Journal of Mathematical Biology (Search for Journal in Brave)
Abstract: This paper deals with the derivation of a collective model of cell populations out of an individual-based description of the underlying physical particle system. By looking at the spatial distribution of cells in terms of time-evolving measures, rather than at individual cell paths, we obtain an ensemble representation stemming from the phenomenological behavior of the single component cells. In particular, as a key advantage of our approach, the scale of representation of the system, i.e., microscopic/discrete vs. macroscopic/continuous, can be chosen a posteriori according only to the spatial structure given to the aforesaid measures. The paper focuses in particular on the use of different scales based on the specific functions performed by cells. A two-population hybrid system is considered, where cells with a specialized/differentiated phenotype are treated as a discrete population of point masses while unspecialized/undifferentiated cell aggregates are represented with a continuous approximation. Numerical simulations and analytical investigations emphasize the role of some biologically relevant parameters in determining the specific evolution of such a hybrid cell system.
Full work available at URL: https://arxiv.org/abs/1108.1212
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PDEs in connection with biology, chemistry and other natural sciences (35Q92) Cell movement (chemotaxis, etc.) (92C17)
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Cited In (23)
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