HIV vs. the immune system: a differential game

DOI10.3390/MATH3041139MaRDI QIDQ901467zbMATH OpenOpenAlexFDO

Authors Alessandra Buratto, Rudy Cesaretto, Rita Zamarchi

Publication date 12 January 2016

Published in Mathematics (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.3390/math3041139

zbMATH Keywords

differential gamesHIVimmune systemmathematical modelingoptimal structured treatment interruption

Mathematics Subject Classification ID

Differential games and control (49N70) Applications of optimal control and differential games (49N90) Differential games (aspects of game theory) (91A23) Medical applications (general) (92C50)

Review text

Summary: A differential game is formulated in order to model the interaction between the immune system and the HIV virus. One player is represented by the immune system of a patient subject to a therapeutic treatment and the other player is the HIV virus. The aim of our study is to determine the optimal therapy that allows to prevent viral replication inside the body, so as to reduce the damage caused to the immune system, and allow greater survival and quality of life. We propose a model that considers all the most common classes of antiretroviral drugs taking into account different immune cells dynamics. We validate the model with numerical simulations, and determine optimal Structured Treatment Interruption (STI) schedules for medications.

Recommendations

• Optimal HIV treatment by maximising immune response
• Dynamic multidrug therapies for HIV: Optimal and STI control approaches
• scientific article; zbMATH DE number 1247361
• A model for interactions between immune cells and HIV considering drug treatments
• Optimal control of the chemotherapy of HIV

Cites work

• A numerical method for solving optimal control problems
• A stochastic model for internal HIV dynamics
• Control of the medical treatment of AIDS
• scientific article; zbMATH DE number 3992265 (Why is no real title available?)
• Immunotherapy of HIV-1 infection
• Mathematical Biology
• Numerical methods of optimal control of the HIV-infection dynamics
• Optimal control of an HIV immunology model
• Short and long period optimization of drug doses in the treatment of AIDS
• Some state space models of HIV pathogenesis under treatment by anti-viral drugs in HIV-infected individuals
• State estimation and optimal long period clinical treatment of HIV seropositive patients

Cited in

(6)

• Stability analysis and memetic computation using differential evolution for in-host HIV model
• Do charities spend more on their social programs when they cooperate than when they compete?
• Tracking problem under bounded disturbances: algebraic synthesis method
• Multiplayer games and HIV transmission via casual encounters
• On building two-player games with treatment schedules for the SIR model
• Evolutionary game theoretic strategy for optimal drug delivery to influence selection pressure in treatment of HIV-1

Describes a project that uses

Uses Software

• Maple
• Matlab

This page was built for publication: HIV vs. the immune system: a differential game

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q901467)