An approximate likelihood approach to nonlinear mixed effects models via spline approximation

DOI10.1016/j.csda.2003.10.011zbMath1429.62278OpenAlexW1972915120MaRDI QIDQ956980

Zhiyu Ge, John A. Rice, Peter J. Bickel

Publication date: 26 November 2008

Published in: Computational Statistics and Data Analysis (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.csda.2003.10.011

zbMATH Keywords

consistencyefficiencyspline approximationapproximate likelihoodgeneralized estimating equationnonlinear mixed effects modelpopulation pharmacokinetics

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Point estimation (62F10) General nonlinear regression (62J02)

Related Items (2)

Lasso-type estimators for semiparametric nonlinear mixed-effects models estimation ⋮ Extension of the SAEM algorithm for nonlinear mixed models with 2 levels of random effects

Uses Software

• S-PLUS
• NONMEM

Cites Work

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• Semi-Nonparametric Maximum Likelihood Estimation
• Estimation of nonlinear random coefficent models
• Latin supercube sampling for very high-dimensional simulations
• The nonlinear mixed effects model with a smooth random effects density
• Laplace's approximation for nonlinear mixed models
• A New Method to Explore the Distribution of Interindividual Random Effects in Non-Linear Mixed Effects Models
• An EM Algorithm for Nonlinear Random Effects Models
• Physiological Pharmacokinetic Analysis Using Population Modeling and Informative Prior Distributions
• Mixed-Effects Models in S and S-PLUS

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