Parameter identification and model verification in systems of partial differential equations applied to transdermal drug delivery

DOI10.1016/J.MATCOM.2008.02.025MaRDI QIDQ960350zbMATH OpenOpenAlexFDO

Authors Klaus Schittkowski

Publication date 17 December 2008

Published in Mathematics and Computers in Simulation (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.matcom.2008.02.025

zbMATH Keywords

parameter estimationconfidence intervalnumerical resultsMichaelis-Menten kineticsoptimum experimental designmethod of linesdata fittingpartial differential equationpharmaceutical systemtransdermal application

Mathematics Subject Classification ID

Point estimation (62F10) Optimal statistical designs (62K05) Nonlinear parabolic equations (35K55) Method of lines for initial value and initial-boundary value problems involving PDEs (65M20) Numerical methods for inverse problems for initial value and initial-boundary value problems involving PDEs (65M32) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Recommendations

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• A numerical treatment of the release of drug in nonswelling transdermal drug-delivery devices
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Cites work

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Cited in

(5)

• Approximating coupled hyperbolic-parabolic systems arising in enhanced drug delivery
• Optimal Adaptive Designs with Inverse Ordinary Differential Equations
• A numerical treatment of the release of drug in nonswelling transdermal drug-delivery devices
• Method on estimation of drug's penetrated parameters
• Repeated applications of a transdermal patch: Analytical solution and optimal control of the delivery rate

Describes a project that uses

Uses Software

• PCOMP
• PDEFIT
• NLPQLP
• RODAS
• Schittkowski
• NL2SOL
• EASY - FIT
• NLPQL
• DFNLP

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