Simultaneous non-Gaussian component analysis (SING) for data integration in neuroimaging

DOI10.1214/21-AOAS1466zbMATH Open1478.62341arXiv2005.00597MaRDI QIDQ96915FDOQ96915

Authors: Benjamin B. Risk, Irina Gaynanova, Benjamin B. Risk 

Publication date: 1 September 2021

Published in: The Annals of Applied Statistics (Search for Journal in Brave)

Abstract: As advances in technology allow the acquisition of complementary information, it is increasingly common for scientific studies to collect multiple datasets. Large-scale neuroimaging studies often include multiple modalities (e.g., task functional MRI, resting-state fMRI, diffusion MRI, and/or structural MRI), with the aim to understand the relationships between datasets. In this study, we seek to understand whether regions of the brain activated in a working memory task relate to resting-state correlations. In neuroimaging, a popular approach uses principal component analysis for dimension reduction prior to canonical correlation analysis with joint independent component analysis, but this may discard biological features with low variance and/or spuriously associate structure unique to a dataset with joint structure. We introduce Simultaneous Non-Gaussian component analysis (SING) in which dimension reduction and feature extraction are achieved simultaneously, and shared information is captured via subject scores. We apply our method to a working memory task and resting-state correlations from the Human Connectome Project. We find joint structure as evident from joint scores whose loadings highlight resting-state correlations involving regions associated with working memory. Moreover, some of the subject scores are related to fluid intelligence.

Full work available at URL: https://arxiv.org/abs/2005.00597

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zbMATH Keywords

multiviewmultiblockcanonical correlation analysisdata fusionindependent component analysisJIVEmultimodalityprojection pursuitunsupervised learning

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Learning and adaptive systems in artificial intelligence (68T05) Measures of association (correlation, canonical correlation, etc.) (62H20) Image analysis in multivariate analysis (62H35)

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Cited In (5)

• ICA for fusion of brain imaging data
• Group linear non-Gaussian component analysis with applications to neuroimaging
• Sparse Independent Component Analysis with an Application to Cortical Surface fMRI Data in Autism
• singR
• Double-Matched Matrix Decomposition for Multi-View Data

Uses Software

• JIVE
• PMA
• GitHub

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