Diagnosing glaucoma progression with visual field data using a spatiotemporal boundary detection method

DOI10.1080/01621459.2018.1537911zbMATH Open1428.62469arXiv1805.11636OpenAlexW2806242031WikidataQ90991252 ScholiaQ90991252MaRDI QIDQ97699FDOQ97699

Jean-Claude Mwanza, Samuel I. Berchuck, Samuel Berchuck, Joshua L. Warren, Joshua L. Warren, Jean-Claude Mwanza

Publication date: 29 May 2018

Published in: Journal of the American Statistical Association (Search for Journal in Brave)

Abstract: Diagnosing glaucoma progression is critical for limiting irreversible vision loss. A common method for assessing glaucoma progression uses a longitudinal series of visual fields (VF) acquired at regular intervals. VF data are characterized by a complex spatiotemporal structure due to the data generating process and ocular anatomy. Thus, advanced statistical methods are needed to make clinical determinations regarding progression status. We introduce a spatiotemporal boundary detection model that allows the underlying anatomy of the optic disc to dictate the spatial structure of the VF data across time. We show that our new method provides novel insight into vision loss that improves diagnosis of glaucoma progression using data from the Vein Pulsation Study Trial in Glaucoma and the Lions Eye Institute trial registry. Simulations are presented, showing the proposed methodology is preferred over existing spatial methods for VF data. Supplementary materials for this article are available online and the method is implemented in the R package womblR.

Full work available at URL: https://arxiv.org/abs/1805.11636

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zbMATH Keywords

areal womblingBayesian methodsconditional autoregressive modelsdissimilarity metric

Mathematics Subject Classification ID

Directional data; spatial statistics (62H11) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites Work

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Cited In (9)

• Title not available (Why is that?)
• Identifying boundaries in spatially continuous risk surfaces from spatially aggregated disease count data
• A Shape-based Glaucoma Index for Tomographic Images
• Computational Science - ICCS 2004
• Estimation of the defect status on visual field longitudinal data
• womblR
• Bayesian Non-Parametric Factor Analysis for Longitudinal Spatial Surfaces
• Improved inference for areal unit count data using graph-based optimisation
• A spatially varying hierarchical random effects model for longitudinal macular structural data in glaucoma patients

Uses Software

• R
• Rcpp
• spBayes
• BayesDA
• pyuvdata

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