Bayesian semiparametric functional mixed models for serially correlated functional data, with application to glaucoma data
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Publication:5231475
DOI10.1080/01621459.2018.1476242zbMATH Open1420.62456arXiv1802.08727OpenAlexW2963013342WikidataQ93001605 ScholiaQ93001605MaRDI QIDQ5231475FDOQ5231475
Authors: Wonyul Lee, Michelle F. Miranda, Philip Rausch, Veerabhadran Baladandayuthapani, Massimo Fazio, J. Crawford Downs, Jeffrey S. Morris 
Publication date: 27 August 2019
Published in: Journal of the American Statistical Association (Search for Journal in Brave)
Abstract: Glaucoma, a leading cause of blindness, is characterized by optic nerve damage related to intraocular pressure (IOP), but its full etiology is unknown. Researchers at UAB have devised a custom device to measure scleral strain continuously around the eye under fixed levels of IOP, which here is used to assess how strain varies around the posterior pole, with IOP, and across glaucoma risk factors such as age. The hypothesis is that scleral strain decreases with age, which could alter biomechanics of the optic nerve head and cause damage that could eventually lead to glaucoma. To evaluate this hypothesis, we adapted Bayesian Functional Mixed Models to model these complex data consisting of correlated functions on spherical scleral surface, with nonparametric age effects allowed to vary in magnitude and smoothness across the scleral surface, multi-level random effect functions to capture within-subject correlation, and functional growth curve terms to capture serial correlation across IOPs that can vary around the scleral surface. Our method yields fully Bayesian inference on the scleral surface or any aggregation or transformation thereof, and reveals interesting insights into the biomechanical etiology of glaucoma. The general modeling framework described is very flexible and applicable to many complex, high-dimensional functional data.
Full work available at URL: https://arxiv.org/abs/1802.08727
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functional data analysisfunctional regressionsmoothing splinesfunctional mixed modelsnonparametric effectslongitudinal functional data
Nonparametric regression and quantile regression (62G08) Linear regression; mixed models (62J05) Applications of statistics to biology and medical sciences; meta analysis (62P10) Ridge regression; shrinkage estimators (Lasso) (62J07)
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Cited In (12)
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- Functional Bayesian networks for discovering causality from multivariate functional data
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- Regression Analysis of Asynchronous Longitudinal Functional and Scalar Data
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