Automated analysis of quantitative image data using isomorphic functional mixed models, with application to proteomics data
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Publication:641144
DOI10.1214/10-AOAS407zbMATH Open1454.62367arXiv1108.3910WikidataQ30508519 ScholiaQ30508519MaRDI QIDQ641144FDOQ641144
Authors: Jeffrey S. Morris, Veerabhadran Baladandayuthapani, Richard C. Herrick, Pietro Sanna, Howard Gutstein 
Publication date: 21 October 2011
Published in: The Annals of Applied Statistics (Search for Journal in Brave)
Abstract: Image data are increasingly encountered and are of growing importance in many areas of science. Much of these data are quantitative image data, which are characterized by intensities that represent some measurement of interest in the scanned images. The data typically consist of multiple images on the same domain and the goal of the research is to combine the quantitative information across images to make inference about populations or interventions. In this paper we present a unified analysis framework for the analysis of quantitative image data using a Bayesian functional mixed model approach. This framework is flexible enough to handle complex, irregular images with many local features, and can model the simultaneous effects of multiple factors on the image intensities and account for the correlation between images induced by the design. We introduce a general isomorphic modeling approach to fitting the functional mixed model, of which the wavelet-based functional mixed model is one special case. With suitable modeling choices, this approach leads to efficient calculations and can result in flexible modeling and adaptive smoothing of the salient features in the data. The proposed method has the following advantages: it can be run automatically, it produces inferential plots indicating which regions of the image are associated with each factor, it simultaneously considers the practical and statistical significance of findings, and it controls the false discovery rate.
Full work available at URL: https://arxiv.org/abs/1108.3910
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waveletsBayesian analysisfalse discovery ratefunctional data analysisimage analysisproteomicsfunctional MRI2D gel electrophoresisfunctional mixed modelsisomorphic transformations
Computational methods for problems pertaining to statistics (62-08) Bayesian inference (62F15) Applications of statistics to biology and medical sciences; meta analysis (62P10)
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- Automated analysis of biomedical data from low to high resolution
- Functional analysis of high-content high-throughput imaging data
- Comparison and contrast of two general functional regression modelling frameworks
- Longitudinal high-dimensional principal components analysis with application to diffusion tensor imaging of multiple sclerosis
- A Study of Mexican Free-Tailed Bat Chirp Syllables: Bayesian Functional Mixed Models for Nonstationary Acoustic Time Series
- Fast Multilevel Functional Principal Component Analysis
- Wavelet-domain regression and predictive inference in psychiatric neuroimaging
- A Unified Analysis of Structured Sonar-Terrain Data Using Bayesian Functional Mixed Models
- Ultra-Fast Approximate Inference Using Variational Functional Mixed Models
- A general framework for functional regression modelling
- Bayesian semiparametric functional mixed models for serially correlated functional data, with application to glaucoma data
- Ecological prediction with nonlinear multivariate time-frequency functional data models
- Robust classification of functional and quantitative image data using functional mixed models
- Recent developments in complex and spatially correlated functional data
- Function-on-function regression for two-dimensional functional data
- An approach for identifying and predicting economic recessions in real-time using time-frequency functional models
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