Studying the emergence of invasiveness in tumours using game theory
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Publication:978650
DOI10.1140/EPJB/E2008-00249-YzbMATH Open1189.91045arXiv0810.4724OpenAlexW2036374135MaRDI QIDQ978650FDOQ978650
Publication date: 25 June 2010
Published in: The European Physical Journal B. Condensed Matter and Complex Systems (Search for Journal in Brave)
Abstract: Tumour cells have to acquire a number of capabilities if a neoplasm is to become a cancer. One of these key capabilities is increased motility which is needed for invasion of other tissues and metastasis. This paper presents a qualitative mathematical model based on game theory and computer simulations using cellular automata. With this model we study the circumstances under which mutations that confer increased motility to cells can spread through a tumour made of rapidly proliferating cells. The analysis suggests therapies that could help prevent the progression towards malignancy and invasiveness of benign tumours.
Full work available at URL: https://arxiv.org/abs/0810.4724
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Medical applications (general) (92C50) Applications of game theory (91A80) Developmental biology, pattern formation (92C15) Cell biology (92C37)
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Cited In (22)
- Dynamical Patterns of Coexisting Strategies in a Hybrid Discrete-continuum Spatial Evolutionary Game Model
- A topology Nash game for tumoral antiangiogenesis
- Modeling the connection between primary and metastatic tumors
- Game theoretical model of cancer dynamics with four cell phenotypes
- Spatial vs. non-spatial eco-evolutionary dynamics in a tumor growth model
- Effects of heterogeneity on cancer: a game theory perspective
- The role of interventions in the cancer evolution-an evolutionary games approach
- Fractionated follow-up chemotherapy delays the onset of resistance in bone metastatic prostate cancer
- How to analyze models of nonlinear public goods
- Game theory of tumor-stroma interactions in multiple myeloma: effect of nonlinear benefits
- Optimization of an \textit{in vitro} chemotherapy to avoid resistant tumours
- The effects of cell compressibility, motility and contact inhibition on the growth of tumor cell clusters using the cellular Potts model
- The contribution of evolutionary game theory to understanding and treating cancer
- MMP-TIMP interactions in cancer invasion: an evolutionary game-theoretical framework
- Cellular Automaton Modeling of Tumor Invasion
- Cooperative success in epithelial public goods games
- Evolution of cell motility in an individual-based model of tumour growth
- Spreading speeds for a two-species competition-diffusion system
- Game theoretical modelling of survival strategies of \textit{Candida albicans} inside macrophages
- Including blood vasculature into a game-theoretic model of cancer dynamics
- Influence of mutations in phenotypically-structured populations in time periodic environment
- Immune evasion through competitive inhibition: the shielding effect of cancer non-stem cells
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