Reaction-diffusion models for morphological patterning of hESCs

DOI10.1007/S00285-021-01674-3MaRDI QIDQ2244903zbMATH OpenOpenAlexWikidataFDO

Authors Prajakta Bedekar, Aryeh Warmflash, Mikhail Perepelitsa, Ilya Timofeyev

Publication date 12 November 2021

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2101.03474

zbMATH Keywords

cell differentiationreaction-diffusion equationsmorphological patterning

Mathematics Subject Classification ID

Stability in context of PDEs (35B35) Existence problems for PDEs: global existence, local existence, non-existence (35A01) Reaction-diffusion equations (35K57) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Finite difference methods for initial value and initial-boundary value problems involving PDEs (65M06) Finite element, Rayleigh-Ritz and Galerkin methods for initial value and initial-boundary value problems involving PDEs (65M60) Finite element, Rayleigh-Ritz and Galerkin methods for boundary value problems involving PDEs (65N30) Computational methods for problems pertaining to biology (92-08) Developmental biology, pattern formation (92C15)

Abstract: In this paper we consider mathematical modeling of the dynamics of self-organized patterning of spatially confined human embryonic stem cells (hESCs) treated with BMP4 (gastruloids) described in recent experimental works. In the first part of the paper we use the activator-inhibitor equations of Gierer and Meinhardt to identify 3 reaction-diffusion regimes for each of the three morphogenic proteins, BMP4, Wnt and Nodal, based on the characteristic features of the dynamic patterning. We identify appropriate boundary conditions which correspond to the experimental setup and perform numerical simulations of the reaction-diffusion (RD) systems, using the finite element approximation, to confirm that the RD systems in these regimes produce realistic dynamics of the protein concentrations. In the second part of the paper we use analytic tools to address the questions of the existence and stability of non-homogeneous steady states for the reaction-diffusion systems of the type considered in the first part of the paper. We find sufficient conditions on the data of the problem under which the system has an universal attractor.

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Cites work

• scientific article; zbMATH DE number 42093 (Why is no real title available?)
• scientific article; zbMATH DE number 3574289 (Why is no real title available?)
• scientific article; zbMATH DE number 3801985 (Why is no real title available?)
• scientific article; zbMATH DE number 5681750 (Why is no real title available?)
• A mechanical model for mesenchymal morphogenesis
• A theory of biological pattern formation
• A user's guide to PDE models for chemotaxis
• Global solutions of reaction-diffusion systems
• New development in freefem++
• Reaction and diffusion on growing domains: scenarios for robust pattern formation
• The chemical basis of morphogenesis
• Turing conditions for pattern forming systems on evolving manifolds
• Turing patterning in stratified domains

Cited in

(6)

• PaReDiSo: a reaction-diffusion solver coupled with OpenMPI and CVODE
• Cell-based simulation of dynamic expression patterns in the presomitic mesoderm
• Individual cell-based models of cell scatter of ARO and MLP-29 cells in response to hepatocyte growth factor
• Multiple stable steady states of a reaction-diffusion model on zebrafish dorsal-ventral patterning
• Quantifying Cellular Pluripotency and Pathway Robustness Through Forman-Ricci Curvature
• A note on a reaction-diffusion model describing the bone morphogen protein gradient in Drosophila embryonic patterning

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Uses Software

• FreeFem++

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