Simplification of a complex signal transduction model using invariants and flow equivalent servers

DOI10.1016/J.TCS.2011.06.013MaRDI QIDQ652148zbMATH OpenOpenAlexWikidataFDO

Authors F. Cordero, Daniele Manini, Lucia Napione, Massimiliano De Pierro, Simona Pavan, Andrea Picco, Andrea Veglio, Matteo Sereno, Federico Bussolino, Gianfranco Balbo, András Horváth

Publication date 19 December 2011

Published in Theoretical Computer Science (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.tcs.2011.06.013

zbMATH Keywords

angiogenesissystems biologyPetri netsmodel simplification

Mathematics Subject Classification ID

Medical applications (general) (92C50) Systems biology, networks (92C42) Models and methods for concurrent and distributed computing (process algebras, bisimulation, transition nets, etc.) (68Q85)

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Cites work

• scientific article; zbMATH DE number 52953 (Why is no real title available?)
• scientific article; zbMATH DE number 3599479 (Why is no real title available?)
• scientific article; zbMATH DE number 1786473 (Why is no real title available?)
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• scientific article; zbMATH DE number 3249395 (Why is no real title available?)
• Michaelis-Menten kinetics at high enzyme concentrations
• Parametric Analysis of Queuing Networks
• Probability, Markov chains, queues, and simulation. The mathematical basis of performance modeling.
• Recent developments in parameter estimation and structure identification of biochemical and genomic systems

Cited in

(4)

• Approximate analysis of biological systems by hybrid switching jump diffusion
• Product form approximation of transient probabilities in stochastic reaction networks
• Model decomposition and reduction tools for large-scale networks in systems biology
• Computational heuristics for simplifying a biological model

Describes a project that uses

Uses Software

• GreatSPN
• Meddly

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