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CRANtiggerMaRDI QIDQ70955

Infers Novel Immunoglobulin Alleles from Sequencing Data

Steven Kleinstein, Susanna Marquez, Moriah Cohen, Daniel Gadala-Maria, Jason vander Heiden, Gur Yaari

Last update: 10 October 2023

Copyright license: GNU Affero General Public License, version 3.0

Software version identifier: 1.0.1, 0.2.5, 0.2.7, 0.2.8, 0.2.9.999, 0.2.10, 0.2.11, 0.3.0, 0.3.1, 0.4.0, 1.0.0, 1.1.0

Description

Infers the V genotype of an individual from immunoglobulin (Ig) repertoire sequencing data (AIRR-Seq, Rep-Seq). Includes detection of any novel alleles. This information is then used to correct existing V allele calls from among the sample sequences. Citations: Gadala-Maria, et al (2015) <doi:10.1073/pnas.1417683112>, Gadala-Maria, et al (2019) <doi:10.3389/fimmu.2019.00129>.

Cites work

• Automated analysis of high-throughput B-cell sequencing data reveals a high frequency of novel immunoglobulin V gene segment alleles
• Identification of Subject-Specific Immunoglobulin Alleles From Expressed Repertoire Sequencing Data

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