Step Contrasts for Identifying the Minimum Effective Dose

DOI10.1081/STA-200045872MaRDI QIDQ4678794zbMATH OpenFDO

Authors Show-Li Jan

Publication date 23 May 2005

Published in Communications in Statistics: Theory and Methods (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1081/STA-200045872

zbMATH Keywords

tablesminimum effective dosetoxicologydrug developmentdose-response studyHelmert contrastspairwise contrastsstep contrastsstep-down test

Mathematics Subject Classification ID

Parametric hypothesis testing (62F03) Nonparametric hypothesis testing (62G10) Applications of statistics to biology and medical sciences; meta analysis (62P10) Monte Carlo methods (65C05)

Recommendations

• Nonparametric equivalents of contrasts for identifying the minimum effective dose
• Simultaneous identifications of the minimum effective dose in each of several groups
• Stepwise Confidence Intervals for Monotone Dose–Response Studies
• Nonparametric Identification of the Minimum Effective Dose
• NONPARAMETRIC IDENTIFICATION OF THE MINIMUM EFFECTIVE DOSE FOR RANDOMIZED BLOCK DESIGNS

Cites work

• Algorithm AS 195: Multivariate Normal Probabilities with Error Bound
• Multiple Test Procedures for Dose Finding
• Some new multiple-test procedures for dose finding

Cited in

(12)

• Simultaneous confidence bounds in monotone dose-response studies
• NONPARAMETRIC IDENTIFICATION OF THE MINIMUM EFFECTIVE DOSE FOR RANDOMIZED BLOCK DESIGNS
• Stepwise procedures for the identification of minimum effective dose with unknown variances
• Identification of the minimum effective dose based on weighted Kaplan-Meier statistics
• Identification of the minimum effective dose for right-censored survival data
• Nonparametric equivalents of contrasts for identifying the minimum effective dose
• Sequential hypothesis tests for identifying the minimum dose with a threshold effect
• Simultaneous identifications of the minimum effective dose in each of several groups
• A novel framework to estimate multidimensional minimum effective doses using asymmetric posterior gain and \(\epsilon\)-tapering
• NONPARAMETRIC STEP-DOWN TEST PROCEDURES FOR FINDING MINIMUM EFFECTIVE DOSE
• Nonparametric Identification of the Minimum Effective Dose
• Inference on the Minimum Effective Dose Using Binary Data

Describes a project that uses

Uses Software

• AS 195
• SAS

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