A novel framework to estimate multidimensional minimum effective doses using asymmetric posterior gain and -tapering

DOI10.1214/21-AOAS1549MaRDI QIDQ2170396zbMATH OpenWikidataFDO

Authors Thevaa Chandereng, Keith M. Diaz, Ying Kuen Cheung

Publication date 5 September 2022

Published in The Annals of Applied Statistics (Search for Journal in Brave)

zbMATH Keywords

adaptive dose-findinggeneralized PIPEglucose monitoringsedentary breaksweighted posterior gain

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Recommendations

• A hybrid method to estimate the minimum effective dose for monotone and non-monotone dose-response relationships
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• Adaptive isotonic estimation of the minimum effective and peak doses in the presence of covariates

Cites work

• A hierarchical Bayesian design for phase I trials of novel combinations of cancer therapeutic agents
• Continual Reassessment Method: A Practical Design for Phase 1 Clinical Trials in Cancer
• Continual reassessment method for partial ordering
• Dose-finding with two agents in phase I oncology trials
• Sequential Designs for Phase I Clinical Trials with Late‐Onset Toxicities
• Sequential Implementation of Stepwise Procedures for Identifying the Maximum Tolerated Dose

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