A novel framework to estimate multidimensional minimum effective doses using asymmetric posterior gain and -tapering

DOI10.1214/21-AOAS1549zbMATH Open1498.62200WikidataQ114060487 ScholiaQ114060487MaRDI QIDQ2170396FDOQ2170396

Authors: Thevaa Chandereng, Keith M. Diaz, Ying Kuen Cheung 

Publication date: 5 September 2022

Published in: The Annals of Applied Statistics (Search for Journal in Brave)

Recommendations

• A hybrid method to estimate the minimum effective dose for monotone and non-monotone dose-response relationships
• Simultaneous identifications of the minimum effective dose in each of several groups
• Step Contrasts for Identifying the Minimum Effective Dose
• NONPARAMETRIC IDENTIFICATION OF THE MINIMUM EFFECTIVE DOSE FOR RANDOMIZED BLOCK DESIGNS
• Adaptive isotonic estimation of the minimum effective and peak doses in the presence of covariates

zbMATH Keywords

adaptive dose-findinggeneralized PIPEglucose monitoringsedentary breaksweighted posterior gain

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites Work

• Continual Reassessment Method: A Practical Design for Phase 1 Clinical Trials in Cancer
• Sequential Designs for Phase I Clinical Trials with Late‐Onset Toxicities
• Dose-finding with two agents in phase I oncology trials
• A hierarchical Bayesian design for phase I trials of novel combinations of cancer therapeutic agents
• Sequential Implementation of Stepwise Procedures for Identifying the Maximum Tolerated Dose
• Continual reassessment method for partial ordering

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