Continual Reassessment Method for Partial Ordering

DOI10.1111/j.1541-0420.2011.01560.xzbMath1274.62892OpenAlexW1976972195WikidataQ30423577 ScholiaQ30423577MaRDI QIDQ2893418

Nolan A. Wages, John O'Quigley, Mark Conaway

Publication date: 20 June 2012

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: http://europepmc.org/articles/pmc3141101

zbMATH Keywords

clinical trialpartial orderingdose-finding studiesmaximum tolerated dosecontinual reassessment methodtoxicitydrug combinationdose escalationphase 1 trials

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Related Items (8)

Semiparametric Dose Finding Methods for Partially Ordered Drug Combinations ⋮ A novel framework to estimate multidimensional minimum effective doses using asymmetric posterior gain and \(\epsilon\)-tapering ⋮ Flexible use of copula‐type model for dose‐finding in drug combination clinical trials ⋮ Adaptive Bayesian phase I clinical trial designs for estimating the maximum tolerated doses for two drugs while fully utilizing all toxicity information ⋮ Evaluation of phase I clinical trial designs for combinational agents along with guidance based on simulation studies ⋮ Bayesian data augmentation dose finding with continual reassessment method and delayed toxicity ⋮ Adaptive clinical trial designs for phase I cancer studies ⋮ A Bayesian adaptive design in cancer phase I trials using dose combinations in the presence of a baseline covariate

Cites Work

• Continual Reassessment Method: A Practical Design for Phase 1 Clinical Trials in Cancer
• Confidence interval estimation subject to order restrictions
• Dose-Finding with Two Agents in Phase I Oncology Trials
• A Latent Contingency Table Approach to Dose Finding for Combinations of Two Agents
• Design and Analysis of Phase I Clinical Trials
• Designs for Single- or Multiple-Agent Phase I Trials
• Coherence principles in dose-finding studies
• Continual Reassessment Method: A Likelihood Approach
• A Parallel Phase I/II Clinical Trial Design for Combination Therapies
• Non-parametric optimal design in dose finding studies
• Two‐Dimensional Dose Finding in Discrete Dose Space

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