Adaptive isotonic estimation of the minimum effective and peak doses in the presence of covariates

DOI10.17615/S915-6112MaRDI QIDQ419309zbMATH OpenOpenAlexWikidataFDO

Authors Changfu Xiao, Anastasia Ivanova

Publication date 18 May 2012

Published in Journal of Statistical Planning and Inference (Search for Journal in Brave)

Full work available at URL https://doi.org/10.17615/s915-6112

zbMATH Keywords

up-and-down designsdose-rangingphase II trials

Mathematics Subject Classification ID

Estimation in survival analysis and censored data (62N02) Applications of statistics to biology and medical sciences; meta analysis (62P10) Medical applications (general) (92C50)

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Cites work

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• Combining Multiple Comparisons and Modeling Techniques in Dose‐Response Studies
• Confidence interval estimation subject to order restrictions
• Constrained Statistical Inference
• Continual Reassessment Method: A Practical Design for Phase 1 Clinical Trials in Cancer
• Continual reassessment method for ordered groups
• Designs for Single- or Multiple-Agent Phase I Trials
• Dose Finding for Continuous and Ordinal Outcomes with a Monotone Objective Function: A Unified Approach
• Dose finding using the biased coin up-and-down design and isotonic regression
• Monitoring late-onset toxicities in phase I trials using predicted risks
• Optimal Bayesian-feasible dose escalation for cancer phase I trials
• Simple Sequential Boundaries for Treatment Selection in Multi‐Armed Randomized Clinical Trials with a Control

Cited in

(1)

• A novel framework to estimate multidimensional minimum effective doses using asymmetric posterior gain and \(\epsilon\)-tapering

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