Adaptive Dc-optimal designs for dose finding based on a continuous efficacy endpoint

DOI10.1002/BIMJ.200900214MaRDI QIDQ3076087zbMATH OpenOpenAlexWikidataFDO

Authors S. Krishna Padmanabhan, Vladimir Dragalin

Publication date 17 February 2011

Published in Biometrical Journal (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1002/bimj.200900214

zbMATH Keywords

adaptive designresponse modelsigmoid \(E_{\max}\) modeltarget dose estimation

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Optimal statistical designs (62K05)

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Cites work

• Combining Multiple Comparisons and Modeling Techniques in Dose‐Response Studies
• On the Equivalence of Constrained and Compound Optimal Designs
• Optimal designs for dose-finding studies
• Optimum experimental designs, with SAS
• Sequential methods in multi-arm clinical trials

Cited in

(19)

• scientific article; zbMATH DE number 7513920 (Why is no real title available?)
• Penalized optimal designs for dose-finding
• On optimal designs for clinical trials: an updated review
• Adaptive isotonic estimation of the minimum effective and peak doses in the presence of covariates
• Adaptive designs for dose-finding based on efficacy-toxicity response
• A comparison of allocation strategies for optimising clinical trial designs under variance heterogeneity
• Locally optimal designs for some dose-response models with continuous endpoints
• Designing dose-finding studies with an active control for exponential families
• Non-parametric optimal design in dose finding studies
• Optimal designs for a multiresponse Emax model and efficient parameter estimation
• On the combination of \(c\)- and \(D\)-optimal designs: general approaches and applications in dose-response studies
• Optimal designs for dose-finding studies
• Multiple-objective optimal designs for studying the dose response function and interesting dose levels
• Dose Finding for Continuous and Ordinal Outcomes with a Monotone Objective Function: A Unified Approach
• Response-adaptive dose-finding under model uncertainty
• Optimal dose‐finding for efficacy–safety models
• Adaptive optimal designs for dose-finding studies based on sigmoid \(E_{\max}\) models
• Adaptive designs for selecting drug combinations based on efficacy-toxicity response
• Design efficiency in dose finding studies

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