Dose Finding Using the Biased Coin Up-and-Down Design and Isotonic Regression

DOI10.1111/j.0006-341X.2002.00171.xzbMath1209.62334WikidataQ52044838 ScholiaQ52044838MaRDI QIDQ3078921

Mario Stylianou, Nancy Flournoy

Publication date: 1 March 2011

Published in: Biometrics (Search for Journal in Brave)

zbMATH Keywords

adaptive designslogistic regressioninference for stochastic processesresponse-driven designstoxicity studiesquantal estimationrandom walk designs

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Non-Markovian processes: estimation (62M09) Sequential statistical design (62L05)

Related Items (18)

Designs for Single- or Multiple-Agent Phase I Trials ⋮ A Latent Contingency Table Approach to Dose Finding for Combinations of Two Agents ⋮ Isotonic regression for metallic microstructure data: estimation and testing under order restrictions ⋮ Performance Measures in Dose‐Finding Experiments ⋮ Adaptive isotonic estimation of the minimum effective and peak doses in the presence of covariates ⋮ The adaptive accelerated biased coin design for phase I clinical trials ⋮ Adaptive clinical trial designs for phase I cancer studies ⋮ Cumulative cohort design for dose-finding ⋮ A Semiparametric Sequential Algorithm for Estimation of Dose–Response Curve ⋮ Up-and-down experiments of first and second order ⋮ A two-stage hybrid procedure for estimating an inverse regression function ⋮ Group up-and-down designs for dose-finding ⋮ Derivation of Exact Distributions Following an Up-and-Down Design ⋮ Efficient algorithms for the inverse sorting problem with bound constraints under the \(l_{\infty }\)-norm and the Hamming distance ⋮ Individualized dosing for multiple ordered groups of patients ⋮ Randomized group up and down experiments ⋮ A New Dose‐Finding Design for Bivariate Outcomes ⋮ Stochastic non-convex envelopment of data: applying isotonic regression to frontier estimation

Cites Work

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• Minimum chi-square, not maximum likelihood!
• Properties of frequency distributions induced by general up-and-down methods for estimating quantiles
• A Comparison of n Estimators for the Binomial Distribution
• A Random Walk Rule for Phase I Clinical Trials
• Toxicity in sequential dose-response experiments
• A Method for Obtaining and Analyzing Sensitivity Data
• The Up-and-Down Method with Small Samples
• Maximum Likelihood and Minimum | chi 2 Estimates of the Logistic Function

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