A New Dose‐Finding Design for Bivariate Outcomes

DOI10.1111/J.0006-341X.2003.00115.XMaRDI QIDQ3433237zbMATH OpenOpenAlexWikidataFDO

Authors Anastasia Ivanova

Publication date 27 April 2007

Published in Biometrics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1111/j.0006-341x.2003.00115.x

zbMATH Keywords

random walkdose-finding studiesup-and-down designphase I trialoptimal dose

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Recommendations

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• Bayesian Dose-Finding in Phase I/II Clinical Trials Using Toxicity and Efficacy Odds Ratios
• Two‐Dimensional Dose Finding in Discrete Dose Space

Cites work

• scientific article; zbMATH DE number 4015964 (Why is no real title available?)
• scientific article; zbMATH DE number 3145626 (Why is no real title available?)
• Dose finding using the biased coin up-and-down design and isotonic regression

Cited in

(15)

• Penalized optimal designs for dose-finding
• Prediction Approaches to Sequentially Searching for an Optimal Dose
• Correlated endpoints: simulation, modeling, and extreme correlations
• Adaptive designs for dose-finding based on efficacy-toxicity response
• Bayesian Dose-Finding in Phase I/II Clinical Trials Using Toxicity and Efficacy Odds Ratios
• Implementation of a Bayesian Design in a Dose‐Escalation Study of an Experimental Agent in Healthy Volunteers
• Adaptive clinical trial designs for phase I cancer studies
• Up-and-Down Designs for Selecting the Dose with Maximum Success Probability
• A Bayesian adaptive design for dual-agent phase I-II oncology trials integrating efficacy data across stages
• Cumulative cohort design for dose-finding
• Dose Finding for Continuous and Ordinal Outcomes with a Monotone Objective Function: A Unified Approach
• Optimizing the concentration and bolus of a drug delivered by continuous infusion
• Patient‐Specific Dose Finding Based on Bivariate Outcomes and Covariates
• Utility-Based Optimization of Combination Therapy Using Ordinal Toxicity and Efficacy in Phase I/II Trials
• Bayesian models and decision algorithms for complex early phase clinical trials

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