A New Dose‐Finding Design for Bivariate Outcomes

DOI10.1111/J.0006-341X.2003.00115.XzbMATH Open1274.62797OpenAlexW2059221883WikidataQ76350547 ScholiaQ76350547MaRDI QIDQ3433237FDOQ3433237

Authors: Anastasia Ivanova 

Publication date: 27 April 2007

Published in: Biometrics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1111/j.0006-341x.2003.00115.x

Recommendations

• Adaptive designs for dose-finding based on efficacy-toxicity response
• Adaptive designs for selecting drug combinations based on efficacy-toxicity response
• Dose-Finding Based on Efficacy-Toxicity Trade-Offs
• Bayesian Dose-Finding in Phase I/II Clinical Trials Using Toxicity and Efficacy Odds Ratios
• Two‐Dimensional Dose Finding in Discrete Dose Space

zbMATH Keywords

random walkdose-finding studiesup-and-down designphase I trialoptimal dose

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites Work

• Title not available (Why is that?)
• Dose finding using the biased coin up-and-down design and isotonic regression
• Title not available (Why is that?)

Cited In (15)

• Bayesian models and decision algorithms for complex early phase clinical trials
• Penalized optimal designs for dose-finding
• A Bayesian adaptive design for dual-agent phase I-II oncology trials integrating efficacy data across stages
• Optimizing the concentration and bolus of a drug delivered by continuous infusion
• Utility-Based Optimization of Combination Therapy Using Ordinal Toxicity and Efficacy in Phase I/II Trials
• Adaptive designs for dose-finding based on efficacy-toxicity response
• Implementation of a Bayesian Design in a Dose‐Escalation Study of an Experimental Agent in Healthy Volunteers
• Bayesian Dose-Finding in Phase I/II Clinical Trials Using Toxicity and Efficacy Odds Ratios
• Cumulative cohort design for dose-finding
• Adaptive clinical trial designs for phase I cancer studies
• Dose Finding for Continuous and Ordinal Outcomes with a Monotone Objective Function: A Unified Approach
• Correlated endpoints: simulation, modeling, and extreme correlations
• Prediction Approaches to Sequentially Searching for an Optimal Dose
• Up-and-Down Designs for Selecting the Dose with Maximum Success Probability
• Patient‐Specific Dose Finding Based on Bivariate Outcomes and Covariates

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