Up-and-Down Designs for Selecting the Dose with Maximum Success Probability

DOI10.1080/07474940701802034zbMATH Open1142.62049OpenAlexW2004490899MaRDI QIDQ5458029FDOQ5458029

Authors Euloge E. Kpamegan, Nancy Flournoy

Publication date 10 April 2008

Published in Sequential Analysis (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1080/07474940701802034

zbMATH Keywords

dose-findingstochastic approximationMarkov chainsefficacyunimodalitytoxicitystationary treatment distributionphase I/II clinical trialrandom walk designsoptimal doseconstant gain stochastic algorithm

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Medical applications (general) (92C50) Sequential statistical design (62L05) Stochastic approximation (62L20)

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Cites work

• scientific article; zbMATH DE number 3493681 (Why is no real title available?)
• scientific article; zbMATH DE number 1005357 (Why is no real title available?)
• A Method for Obtaining and Analyzing Sensitivity Data
• A New Dose‐Finding Design for Bivariate Outcomes
• A Strategy for Dose-Finding and Safety Monitoring Based on Efficacy and Adverse Outcomes in Phase I/II Clinical Trials
• A sequential design for maximizing the probability of a favourable response
• Asymptotic Distribution of Stochastic Approximation Procedures
• Directed walk designs for dose-response problems with competing failure modes
• Dose-finding designs for HIV studies
• Non-Parametric Up-and-down Experimentation
• On a Stochastic Approximation Method
• Optimal Designs for Bivariate Logistic Regression
• Properties of frequency distributions induced by general up-and-down methods for estimating quantiles
• Some Results for Discrete Unimodality
• Stochastic Approximation
• Toxicity in sequential dose-response experiments

Cited in

(9)

• Sequential Implementation of Stepwise Procedures for Identifying the Maximum Tolerated Dose
• Group up-and-down designs for dose-finding
• Adaptive designs for dose-finding based on efficacy-toxicity response
• Up-and-down designs for dose-finding
• Optimal designs and limiting optimal designs for a trinomial response
• Up-and-down experiments of first and second order
• Directed walk designs for dose-response problems with competing failure modes
• A novel technique for stochastic root-finding: enhancing the search with adaptive \(d\)-ary search
• An optimizing up-and-down design

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