An optimizing up-and-down design

DOI10.1007/978-1-4757-3419-5_19MaRDI QIDQ5233891zbMATH OpenOpenAlexFDO

Authors Euloge E. Kpamegan, Nancy Flournoy

Publication date 9 September 2019

Published in Nonconvex Optimization and Its Applications (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/978-1-4757-3419-5_19

zbMATH Keywords

constant gain stochastic algorithmMarkov chainsphase I/II clinical trialrandom walk designsstationary treatment distributionstochastic approximation

Mathematics Subject Classification ID

Sequential statistical design (62L05) Optimal stopping in statistics (62L15) Applications of statistics to biology and medical sciences; meta analysis (62P10)

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Cites work

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• scientific article; zbMATH DE number 3459735 (Why is no real title available?)
• scientific article; zbMATH DE number 3493681 (Why is no real title available?)
• scientific article; zbMATH DE number 524373 (Why is no real title available?)
• scientific article; zbMATH DE number 1361708 (Why is no real title available?)
• scientific article; zbMATH DE number 1361709 (Why is no real title available?)
• scientific article; zbMATH DE number 3322699 (Why is no real title available?)
• Non-Parametric Up-and-down Experimentation
• On a Stochastic Approximation Method
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Cited in

(11)

• Penalized optimal designs for dose-finding
• Group up-and-down designs for dose-finding
• Optimizing the concentration and bolus of a drug delivered by continuous infusion
• Directed walk designs for dose-response problems with competing failure modes
• Prediction Approaches to Sequentially Searching for an Optimal Dose
• A sequential design for maximizing the probability of a favourable response
• An approximate Bayesian up-down method for estimating a percentage point on a dose-response curve
• scientific article; zbMATH DE number 1361708 (Why is no real title available?)
• Optimizing a unimodal response function for binary variables
• Stochastic approximation with virtual observations for dose-finding on discrete levels
• Up-and-Down Designs for Selecting the Dose with Maximum Success Probability

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