Group up-and-down designs for dose-finding

DOI10.1016/j.jspi.2005.08.002zbMath1089.62132MaRDI QIDQ2492509

Nancy Flournoy, Misrak Gezmu

Publication date: 9 June 2006

Published in: Journal of Statistical Planning and Inference (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jspi.2005.08.002

zbMATH Keywords

Markov chains; random walks; birth and death processes; adaptive designs; clinical trials; applied probability; phase I clinical trials; toxicity studies; stationary treatment distribution

Mathematics Subject Classification ID

62G10: Nonparametric hypothesis testing

62P10: Applications of statistics to biology and medical sciences; meta analysis

62L05: Sequential statistical design

62N02: Estimation in survival analysis and censored data

Related Items

Cumulative cohort design for dose-finding, A sequential design for maximizing the probability of a favourable response

Cites Work

• Markovian experiments that approximate optimal designs for quantal response curves
• Operating characteristics of the standard phase I clinical trial design.
• Properties of frequency distributions induced by general up-and-down methods for estimating quantiles
• Up-and-down experiments of first and second order
• Dose Finding Using the Biased Coin Up-and-Down Design and Isotonic Regression
• Design and Analysis of Phase I Clinical Trials
• A Random Walk Rule for Phase I Clinical Trials
• Toxicity in sequential dose-response experiments
• Asymptotic Properties of the Block Up-and-Down Method in Bio-assay
• A Method for Obtaining and Analyzing Sensitivity Data
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