Structure-induced dynamics of erythrocyte aggregates by microscale simulation
Summary: Erythrocyte aggregation and dissociation play an important role in the determination of hemodynamical properties of blood flow in microcirculation. This paper intends to investigate the adhesion and dissociation kinetics of erythrocytes through computational modeling. The technique of immersed boundary-fictitious domain method has been applied to the study of erythrocyte aggregates traversing modeled stenotic microchannels. The effects of stenosis geometry, cell membrane stiffness, and intercellular interaction strength on aggregate hemodynamics including transit velocity are studied. It is found that the width of the stenosis throat and shape of stenosis have a significant influence on the dissociation of the aggregates. Moreover, horizontally orientated erythrocyte aggregates are observed to dissociate much easier than their vertical counterparts under the same simulation conditions. Results from this study contribute to the fundamental understanding and knowledge on the biophysical characteristics of erythrocyte aggregates in microscopic blood flow, which will provide pathological insights into some human diseases, such as malaria.
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- Numerical simulation of red blood cell behavior in a stenosed arteriole using the immersed boundary-lattice Boltzmann method
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- Coupling of Navier–Stokes equations with protein molecular dynamics and its application to hemodynamics
- Hydrodynamic interaction between two red blood cells in simple shear flow: its impact on the rheology of a semi-dilute suspension
- A fictitious domain method for Dirichlet problem and applications
- A fictitious domain method for external incompressible viscous flow modeled by Navier-Stokes equations
- Coupling of Navier–Stokes equations with protein molecular dynamics and its application to hemodynamics
- MICROCIRCULATION AND HEMORHEOLOGY
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- Rheology of red blood cell aggregation by computer simulation
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- Hydrodynamic interaction between two red blood cells in simple shear flow: its impact on the rheology of a semi-dilute suspension
- Dissipative particle dynamics simulation of multiple deformable red blood cells in a vessel
- Using 3D fluid-structure interaction model to analyse the biomechanical properties of erythrocyte
- Diffuse interface model for cell interaction and aggregation with lennard-Jones type potential
- Analysis and prediction of hematocrit in microvascular networks
- Towards realistic blood cell biomechanics in microvascular thrombosis simulations
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