Subgroup identification in dose-finding trials via model-based recursive partitioning

DOI10.1002/SIM.7594MaRDI QIDQ7029572zbMATH OpenFDO

Authors Marius Thomas, Björn Bornkamp, Heidi Seibold

Publication date 10 February 2025

Published in Statistics in Medicine (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1002/SIM.7594

zbMATH Keywords

dose estimationnonlinear modelspersonalized medicineregression trees

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites work

• A regression tree approach to identifying subgroups with differential treatment effects
• A simple method for estimating interactions between a treatment and a large number of covariates
• Computational Pharmacokinetics
• Dose finding in drug development.
• Generalized M‐fluctuation tests for parameter instability
• Handbook of methods for designing, monitoring, and analyzing dose-finding trials
• Model-based recursive partitioning for subgroup analyses
• partykit: a modular toolkit for recursive partytioning in \texttt{R}
• Qualitative interaction trees: a tool to identify qualitative treatment-subgroup interactions
• Tutorial in biostatistics: data-driven subgroup identification and analysis in clinical trials

Cited in

(2)

• Comparing methods to assess treatment effect heterogeneity in general parametric regression models
• Using individualized treatment effects to assess treatment effect heterogeneity

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