Testing for gene-environment interaction under exposure misspecification

DOI10.1111/BIOM.12813MaRDI QIDQ3119893zbMATH OpenOpenAlexWikidataFDO

Authors Ryan Sun, David C. Christiani, Xihong Lin, Raymond J. Carroll

Publication date 13 March 2019

Published in Biometrics (Search for Journal in Brave)

Full work available at URL http://europepmc.org/articles/pmc5943197

zbMATH Keywords

asymptotic biasgenome-wide environmental interaction studies (GWEIS)heteroscedasticitylinear regressionlogistic regressionmodel misspecificationresampling methodssandwich variance

Mathematics Subject Classification ID

Linear regression; mixed models (62J05) Generalized linear models (logistic models) (62J12) Applications of statistics to biology and medical sciences; meta analysis (62P10) Applications of statistics to environmental and related topics (62P12) Epidemiology (92D30)

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Cited in

(16)

• Robust tests for gene-environment interaction in case-control and case-only designs
• Analyzing the genotype-by-environment interactions under a randomization-derived mixed model
• An exposure-weighted score test for genetic associations integrating environmental risk factors
• Combining disease models to test for gene-environment interaction in nuclear families
• Gene-environment interaction testing in family-based association studies with phenotypically ascertained samples: a causal inference approach
• A latent variable approach to study gene-environment interactions in the presence of multiple correlated exposures
• Two-stage testing procedures with independent filtering for genome-wide gene-environment interaction
• A general framework for studying genetic effects and gene-environment interactions with missing data
• A doubly robust test for gene-environment interaction in family-based studies of affected offspring
• Testing and Estimating Gene-Environment Interactions in Family-Based Association Studies
• Joint test of parametric and nonparametric effects in partial linear models for gene-environment interaction
• A Cross-Validated Ensemble Approach to Robust Hypothesis Testing of Continuous Nonlinear Interactions: Application to Nutrition-Environment Studies
• Two‐stage penalized regression screening to detect biomarker–treatment interactions in randomized clinical trials
• Robust identification of gene-environment interactions under high-dimensional accelerated failure time models
• Interaction analysis under misspecification of main effects: some common mistakes and simple solutions
• A data-smoothing approach to explore and test gene-environment interaction in case-parent trios

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