The effect of a random initial value in neural first-passage-time models

DOI10.1016/0025-5564(89)90023-0MaRDI QIDQ1113828zbMATH OpenOpenAlexWikidataFDO

Authors S. H. Smith

Publication date 1989

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL http://www.lib.ncsu.edu/resolver/1840.4/8363

zbMATH Keywords

approximations of Stein's modelconstant inputconstant thresholdeffect of a random initial valueexponential distributionfirst-passage-time distributioninterspike interval distributionsleaky integrator with deterministic trajectoriesOrnstein-Uhlenbeck processparameter estimation proceduresstochastic integrate-and-fire neural modelstruncated normal distributionuniform distributionWiener process with drift

Mathematics Subject Classification ID

Applications of Brownian motions and diffusion theory (population genetics, absorption problems, etc.) (60J70) Physiological, cellular and medical topics (92Cxx)

Review text

The effect of a random initial value is examined in several stochastic integrate-and-fire neural models with a constant threshold and constant input. The three models considered are approximations of Stein's model, namely: (1) a leaky integrator with deterministic trajectories, (2) a Wiener process with drift, and (3) an Ornstein-Uhlenbeck process. For model 1, different distributions for the initial value lead to commonly observed interspike interval distributions. For model 2, a discrete and a uniform distribution for the initial value are examined along with some parameter estimation procedures. For model 3, with a truncated normal distribution for the initial value, the coefficient of variation is shown to be greater than 1, and as the threshold becomes large the first-passage-time distribution approaches an exponential distribution. The relationships among the models and between them and previous models are also discussed, along with the robustness of the model assumptions and methods of their verification. The effects of a random initial value are found to be most pronounced at high firing rates.

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