The inverse problem of magnetorelaxometry imaging

DOI10.1088/1361-6420/AADBBFMaRDI QIDQ4682397zbMATH OpenOpenAlexFDO

Authors Janic Föcke, Daniel Baumgarten, Martin Burger

Publication date 18 September 2018

Published in Inverse Problems (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1802.05937

zbMATH Keywords

ADMMtotal variation regularizationuniquenessmagnetic nanoparticlesinverse source problemmagnetic remanencemagnetorelaxometry imaging

Mathematics Subject Classification ID

Ill-posedness and regularization problems in numerical linear algebra (65F22) Biomedical imaging and signal processing (92C55) Numerical methods for inverse problems for boundary value problems involving PDEs (65N21) Biological applications of optics and electromagnetic theory (78A70) Inverse problems for PDEs (35R30) Numerical methods for ill-posed problems for boundary value problems involving PDEs (65N20) Variational methods applied to problems in optics and electromagnetic theory (78M30)

Abstract: The aim of this paper is to provide a solid mathematical discussion of the inverse problem in Magnetorelaxometry Imaging (MRXI), a currently developed technique for quantitative biomedical imaging using magnetic nanoparticles. We provide a detailed discussion of the mathematical modeling of the forward problems including possible ways to activate and measure, leading to a severely ill-posed linear inverse problem. Moreover, we formulate an idealized version of the inverse problem for infinitesimal small activation coils, which allows for a more detailed analysis of uniqueness issues. We propose a variational regularization approach to compute stable approximations of the solution and discuss its discretization and numerical solution. Results on synthetic are presented and improvements to methods used previously in practice are demonstrated. Finally we give an outlook to further questions and in particular experimental design.

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Cited in

(18)

• Bayesian design of measurements for magnetorelaxometry imaging ^*
• Mathematical methods for restoration of images in magnetism of nanoparticles
• Revised conditions for MRI due to isorotation theorem
• Consistency of a phase field regularisation for an inverse problem governed by a quasilinear Maxwell system
• On the degree of ill-posedness of multi-dimensional magnetic particle imaging
• On identifying magnetized anomalies using geomagnetic monitoring within a magnetohydrodynamic model
• Optimizing excitation coil currents for advanced magnetorelaxometry imaging
• On magnetostatic tomography
• Mathematical imaging using electric or magnetic nanoparticles as contrast agents
• Identifying varying magnetic anomalies using geomagnetic monitoring
• Erratum
• The solution of the biomagnetic inverse problem by maximum statistical entropy
• A basic inverse problem in the magnetic force microscopy of linear magnetic materials
• Parameter identification for the Landau-Lifshitz-Gilbert equation in magnetic particle imaging
• Boundary Element Method for an Inverse Problem in Magnetic Resonance Imaging Gradient Coils
• Inverse analysis of magnetic charge densities using discrete Fourier transform with Tikhonov regularization
• Reconstruction of magnetic susceptibility using full magnetic gradient data
• Inverse problem in quantitative susceptibility mapping

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