Time delay in necrotic core formation

DOI10.3934/MBE.2005.2.461MaRDI QIDQ814655zbMATH OpenOpenAlexFDO

Authors Marek Bodnar, Urszula Foryś

Publication date 7 February 2006

Published in Mathematical Biosciences and Engineering (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.3934/mbe.2005.2.461

zbMATH Keywords

functional differential equationsnecrotic core formationtime delay

Mathematics Subject Classification ID

Stability theory of functional-differential equations (34K20) Qualitative investigation and simulation of models involving functional-differential equations (34K60) Cell biology (92C37)

Review text

A simple model of avascular solid tumor dynamics is studied in this paper. The model is derived on the basis of reaction-diffusion dynamics and mass conservation law. They introduce time delay in a cell proliferation process. In the case studied in this paper, the model reduces to one ordinary functional differential equation. The main goal of this paper is to study the process of the necrotic core formation and possible influence of the delay on it. Existence, uniqueness and stability of the steady state are discussed. Numerical simulations are performed.

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Cited in

(41)

• The effect of time delays on the dynamics of avascular tumor growth
• Periodic and non-periodic combination resonance in kinematically excited system of rods.
• Time delays in proliferation process for solid avascular tumour
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• Global existence and uniqueness of solutions for a free boundary problem modeling the growth of tumors with a necrotic core and a time delay in process of proliferation
• Analysis of a free boundary problem for tumor growth with Gibbs-Thomson relation and time delays
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• Analysis of a delayed free boundary problem with application to a model for tumor growth of angiogenesis
• Steady-state analysis of necrotic core formation for solid avascular tumors with time delays in regulatory apoptosis
• Analysis of mathematical models for the growth of tumors with time delays in cell proliferation
• Qualitative analysis of a time-delayed free boundary problem for tumor growth under the action of external inhibitors
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• Analysis of a free boundary problem modeling the growth of nonnecrotic tumors with time delays in proliferation
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• A free boundary problem for necrotic tumor growth with angiogenesis
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• Hopf bifurcation in a solid avascular tumour growth model with two discrete delays

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