tlsR

MaRDI QIDQ7378629CRANFDO

Authors Ali Amiryousefi, Jeremiah Wala

Last update 23 April 2026

Copyright license MIT license, File License

Software version identifier PACKAGES.rds, 0.1.2, 0.2.0, 0.3.0

Description

Fast, reproducible detection and quantitative analysis of tertiary lymphoid structures (TLS) in multiplexed tissue imaging. Implements Independent Component Analysis Trace (ICAT) index, local Ripley's K scanning, automated K Nearest Neighbor (KNN)-based TLS detection, and T-cell clusters identification as described in Amiryousefi et al. (2025) <doi:10.1101/2025.09.21.677465>.

Cites work

• Spatial statistics for identifying and scoring immune clusters in high-plex profiles of primary prostate cancer

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