Towards monitoring critical microscopic parameters for electropermeabilization
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Homogenization in context of PDEs; PDEs in media with periodic structure (35B27) Dependence of solutions to PDEs on initial and/or boundary data and/or on parameters of PDEs (35B30) PDEs in connection with optics and electromagnetic theory (35Q60) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Inverse problems for PDEs (35R30)
Abstract: Electropermeabilization is a clinical technique in cancer treatment to locally stimulate the cell metabolism. It is based on electrical fields that change the properties of the cell membrane. With that, cancer treatment can reach the cell more easily. Electropermeabilization occurs only with accurate dosage of the electrical field. For applications, a monitoring for the amount of electropermeabilization is needed. It is a first step to image the macroscopic electrical field during the process. Nevertheless, this is not complete, because electropermeabilization depends on critical individual properties of the cells such as their curvature. From the macroscopic field, one cannot directly infer that microscopic state. In this article, we study effective parameters in a homogenization model as the next step to monitor the microscopic properties in clinical practice. We start from a physiological cell model for electropermeabilization and analyze its well-posedness. For a dynamical homogenization scheme, we prove convergence and then analyze the effective parameters, which can be found by macroscopic imaging methods. We demonstrate numerically the sensitivity of these effective parameters to critical microscopic parameters governing electropermeabilization. This opens the door to solve the inverse problem of rreconstructing these parameters.
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Cited in
(10)- ``Classical electropermeabilization modeling at the cell scale
- Optimal placement of electrodes in an electroporation process
- Multiple traces formulation and semi-implicit scheme for modelling biological cells under electrical stimulation
- Derivation of cable equation by multiscale analysis for a model of myelinated axons
- Cell scale modeling of electropermeabilization by periodic pulses
- Numerical modelling challenges for clinical electroporation ablation technique of liver tumors
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- Cell electropermeabilization modeling via multiple traces formulation and time semi-implicit multistep coupling
- On the Formation of Glass Microelectrodes
- A Voronoi interface approach to cell aggregate electropermeabilization
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