Valid data-driven subgroup selection with uniform guarantees in clinical trials

DOI10.1002/SIM.70745MaRDI QIDQ7405423zbMATH OpenFDO

Authors Manuel M. Müller, Björn Bornkamp, Frank Bretz, Timothy I. Cannings, Wei Liu, Henry W. J. Reeve, Richard Samworth, Nikolaos Sfikas, Fang Wan, Konstantinos Sechidis

Publication date 2026

Published in Statistics in Medicine (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1002/SIM.70745

zbMATH Keywords

nonparametric regressionparametric regressionsubgroup analysissubgroup discoverytreatment effect heterogeneityType I error rate

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites work

• A Bayesian credible subgroups approach to identifying patient subgroups with positive treatment effects
• A multiple testing method for hypotheses structured in a directed acyclic graph
• A regression tree approach to identifying subgroups with differential treatment effects
• Comparing algorithms for characterizing treatment effect heterogeneity in randomized trials
• Confidence sets for a level set in linear regression
• Demystifying Statistical Learning Based on Efficient Influence Functions
• Estimation and Inference of Heterogeneous Treatment Effects using Random Forests
• scientific article; zbMATH DE number 3860199 (Why is no real title available?)
• scientific article; zbMATH DE number 1779487 (Why is no real title available?)
• Interaction trees with censored survival data
• Isotonic subgroup selection
• Model-based recursive partitioning for subgroup analyses
• Modern approaches for evaluating treatment effect heterogeneity from clinical trials and observational data
• Optimal subgroup selection
• Optimally weighted, fixed sequence and gatekeeper multiple testing procedures
• Patterns of treatment effects in subsets of patients in clinical trials
• Recursive partitioning for heterogeneous causal effects
• The sequential rejection principle of familywise error control
• Towards optimal doubly robust estimation of heterogeneous causal effects
• Tutorial in biostatistics: data-driven subgroup identification and analysis in clinical trials
• Tutorial on statistical considerations on subgroup analysis in confirmatory clinical trials
• Using individualized treatment effects to assess treatment effect heterogeneity
• Using knockoffs for controlled predictive biomarker identification
• Using simulation studies to evaluate statistical methods

This page was built for publication: Valid data-driven subgroup selection with uniform guarantees in clinical trials

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q7405423)