Drug-Induced TdP Risk Assessment (Q4834866): Difference between revisions
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Removed claim: author (P16): Oleksandr Zadorozhnyi (Q2325377) |
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Drug-Induced TdP Risk Assessment | |||||||||||||||||||||||||||
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Dataset | Dataset in the Graphical Modelling and Causal Inference Zenodo Community | ||||||||||||||||||||||||||
| Property / publication date | Property / publication date | ||||||||||||||||||||||||||
| 27 July 2020
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| Property / author: Oleksandr Zadorozhnyi / rank | |||||||||||||||||||||||||||
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| Property / DOI: 10.5281/zenodo.8058964 / rank | |||||||||||||||||||||||||||
| Property / P1457 (Deleted Property) | |||||||||||||||||||||||||||
| Property / P1457 (Deleted Property): A manually collected dataset that investigates the proarrhythmic risk of 109 drugs using parameters obtained from biophysical models. The dataset defines 4 torsade de pointes (TdP) risk categories in the parameter "class" . For each of 109 drugs, IC50 values and Hill coefficients (h) for INa, INaL, IKr, Ito, ICaL, IK1, and IKs and human effective free therapeutic plasma concentration (EFTPC) were obtained. Detailed description follows. A dash in the dataset means that no value was found publicly available, thus it was considered that the drug effect on that current was negligible. The dataset can be used (and is important) while studing causal discovery methods to infer ion channels selection for the drug-induced TdP risk. Property P1457 not found, cannot determine the data type to use. / rank | |||||||||||||||||||||||||||
| Property / cites work | |||||||||||||||||||||||||||
| Property / cites work: In Silico Classifiers for the Assessment of Drug Proarrhythmicity / rank | |||||||||||||||||||||||||||
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| Property / description | |||||||||||||||||||||||||||
A manually collected dataset that investigates the proarrhythmic risk of 109 drugs using parameters obtained from biophysical models. The dataset provides 4 torsade de pointes (TdP) risk categories. For all 109 drugs, IC50 values and Hill coefficients (h) for INa, INaL, IKr, Ito, ICaL, IK1, and IKs and human effective free therapeutic plasma concentration (EFTPC) were obtained (Llopis-Lorente et al., 2020). | |||||||||||||||||||||||||||
| Property / description: A manually collected dataset that investigates the proarrhythmic risk of 109 drugs using parameters obtained from biophysical models. The dataset provides 4 torsade de pointes (TdP) risk categories. For all 109 drugs, IC50 values and Hill coefficients (h) for INa, INaL, IKr, Ito, ICaL, IK1, and IKs and human effective free therapeutic plasma concentration (EFTPC) were obtained (Llopis-Lorente et al., 2020). / rank | |||||||||||||||||||||||||||
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| Property / community: Graphical Modelling and Causal Inference / rank | |||||||||||||||||||||||||||
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| Property / DOI | |||||||||||||||||||||||||||
| Property / DOI: 10.5281/ZENODO.8058964 / rank | |||||||||||||||||||||||||||
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| Property / cites work | |||||||||||||||||||||||||||
| Property / cites work: In Silico Classifiers for the Assessment of Drug Proarrhythmicity / rank | |||||||||||||||||||||||||||
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Latest revision as of 11:29, 18 April 2025
Dataset in the Graphical Modelling and Causal Inference Zenodo Community
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Drug-Induced TdP Risk Assessment |
Dataset in the Graphical Modelling and Causal Inference Zenodo Community |
Statements
27 July 2020
0 references
A manually collected dataset that investigates the proarrhythmic risk of 109 drugs using parameters obtained from biophysical models. The dataset provides 4 torsade de pointes (TdP) risk categories. For all 109 drugs, IC50 values and Hill coefficients (h) for INa, INaL, IKr, Ito, ICaL, IK1, and IKs and human effective free therapeutic plasma concentration (EFTPC) were obtained (Llopis-Lorente et al., 2020).
0 references
