Drug-Induced TdP Risk Assessment (Q4834866): Difference between revisions
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EloiFerrer (talk | contribs) Removed claim: Property:P1457: A manually collected dataset that investigates the proarrhythmic risk of 109 drugs using parameters obtained from biophysical models. The dataset defines 4 torsade de pointes (TdP) risk categories in the parameter "class" . For each of 109 drugs, IC50 values and Hill coefficients (h) for INa, INaL, IKr, Ito, ICaL, IK1, and IKs and human effective free therapeutic plasma concentration (EFTPC) were obtained. Detailed description follows. A dash... |
Removed claim: author (P16): Oleksandr Zadorozhnyi (Q2325377) |
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Drug-Induced TdP Risk Assessment | |||||||||||||||||||||||||||
| description / en | description / en | ||||||||||||||||||||||||||
Dataset | Dataset in the Graphical Modelling and Causal Inference Zenodo Community | ||||||||||||||||||||||||||
| Property / publication date | Property / publication date | ||||||||||||||||||||||||||
| 27 July 2020
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| Property / author: Oleksandr Zadorozhnyi / rank | |||||||||||||||||||||||||||
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| Property / DOI: 10.5281/zenodo.8058964 / rank | |||||||||||||||||||||||||||
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| Property / cites work: In Silico Classifiers for the Assessment of Drug Proarrhythmicity / rank | |||||||||||||||||||||||||||
| Property / description | Property / description | ||||||||||||||||||||||||||
A manually collected dataset that investigates the proarrhythmic risk of 109 drugs using parameters obtained from biophysical models. The dataset provides 4 torsade de pointes (TdP) risk categories. For all 109 drugs, IC50 values and Hill coefficients (h) for INa, INaL, IKr, Ito, ICaL, IK1, and IKs and human effective free therapeutic plasma concentration (EFTPC) were obtained (Llopis-Lorente et al., 2020). | |||||||||||||||||||||||||||
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| Property / author: MaRDI / rank | |||||||||||||||||||||||||||
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| Property / author: MaRDI / qualifier | |||||||||||||||||||||||||||
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| Property / community: Graphical Modelling and Causal Inference / rank | |||||||||||||||||||||||||||
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| Property / DOI: 10.5281/ZENODO.8058964 / rank | |||||||||||||||||||||||||||
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| Property / cites work: In Silico Classifiers for the Assessment of Drug Proarrhythmicity / rank | |||||||||||||||||||||||||||
Normal rank | |||||||||||||||||||||||||||
Latest revision as of 11:29, 18 April 2025
Dataset in the Graphical Modelling and Causal Inference Zenodo Community
| Language | Label | Description | Also known as |
|---|---|---|---|
| English | Drug-Induced TdP Risk Assessment |
Dataset in the Graphical Modelling and Causal Inference Zenodo Community |
Statements
27 July 2020
0 references
A manually collected dataset that investigates the proarrhythmic risk of 109 drugs using parameters obtained from biophysical models. The dataset provides 4 torsade de pointes (TdP) risk categories. For all 109 drugs, IC50 values and Hill coefficients (h) for INa, INaL, IKr, Ito, ICaL, IK1, and IKs and human effective free therapeutic plasma concentration (EFTPC) were obtained (Llopis-Lorente et al., 2020).
0 references
