Low-intensity combination chemotherapy maximizes host survival time for tumors containing drug-resistant cells (Q1196633): Difference between revisions

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Latest revision as of 08:55, 30 July 2024

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Low-intensity combination chemotherapy maximizes host survival time for tumors containing drug-resistant cells
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    Low-intensity combination chemotherapy maximizes host survival time for tumors containing drug-resistant cells (English)
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    16 January 1993
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    The authors pose the following question. Given a tumor of size \(N(t)\) and two therapeutical agents \(A\) and \(B\), such that parts of the tumor can develop a resistance against \(A\) or \(B\) or both. What is the best application scheme to maximize the survival time defined by \(\sup\{t;N(t)<N_{\max}\}\)? After describing the system by a system of ordinary differential equations with interaction terms the authors reduce the question in several steps to a sequence of discrete problems that can be tackled by nonlinear optimization techniques developed by one of the authors. It turns out that high doses are not optimal and that it is better to keep the size of the tumor constant on a high level.
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    clinical trials
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    drug-resistant cells
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    drug concentration
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    dose intensity
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    drug toxicity
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    host survival time
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    fixed terminal time problems
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    Gompertz tumor growth
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    simulations
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    exponential and logistic tumor growth models
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    combinations of drugs
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    cancer chemotherapy
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    nonlinear optimization
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